Cytohesin 2 Antikörper (N-Term)

Produktnummer ABIN374897

Produktdetails anti-Cytohesin 2 Antikörper

Target: Cytohesin 2 (CYTH2)

Bindungsspezifität: N-Term

Reaktivität: Human, Ratte, Maus, Hund

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser Cytohesin 2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: This antibody reacts to ARNO / cytohesin 2.

Kreuzreaktivität (Details): Species reactivity (expected):Mouse, Canine.
Species reactivity (tested):Human, Rat.

Aufreinigung: Affinity chromatography

Immunogen: Peptide with sequence EDGVYEPPDLTP-C, from the N Terminus of the protein sequence

Anwendungsinformationen

Applikationshinweise: Peptide ELISA: 1/32000. Western Blot: 0.5 - 1.5 μg/mL.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0,5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu Cytohesin 2

Target: Cytohesin 2 (CYTH2)

Andere Bezeichnung: Cytohesin 2 (CYTH2 Produkte)

Synonyme: ARNO antikoerper, CTS18 antikoerper, CTS18.1 antikoerper, PSCD2 antikoerper, PSCD2L antikoerper, SEC7L antikoerper, Sec7p-L antikoerper, Sec7p-like antikoerper, CLM2 antikoerper, Pscd2 antikoerper, Arno antikoerper, Sec7 antikoerper, Sec7B antikoerper, pscd2 antikoerper, MGC84366 antikoerper, CYTH2 antikoerper, cyth2 antikoerper, cytohesin 2 antikoerper, cytohesin-2 antikoerper, cytohesin 2 L homeolog antikoerper, si:dkey-283b15.4 antikoerper, CYTH2 antikoerper, PTRG_08834 antikoerper, Cyth2 antikoerper, cyth2.L antikoerper, cyth2 antikoerper, si:dkey-283b15.4 antikoerper

Hintergrund: The ADP-ribosylation factor (Arf) family comprises a group of structurally and functionally conserved 21 kDa proteins, which are members of the Ras superfamily of regulatory GTP-binding proteins. Arf is involved in intracellular protein traffic to and within the Golgi complex. Arf has a number of disparate activities including maintenance of organelle integrity, assembly of coat proteins, as a co-factor for cholera toxin and as an activator of phospholipase D. Like other small GTPases, Arf is found to be active when bound to GTP and inactive when bound to GDP. Arf's activation is dependent upon guanine nucleotide exchange factors (GEFs) which increase the rate of exchange of bound GDP with GTP. All GEFs have a highly conserved Sec7 domain. GEF activity lies in the Sec7 domain and this activity has been shown to be inhibited by the fungal metabolite brefeldin-A (BFA). A small group of GEFs which are insensitive to brefeldin-A (BFA) include cytohesin-1 (B2-1), cytohesin-2 (ARNO), cytohesin-3 (ARNO3), and cytohesin-4. All cytohesins function in the cell periphery and contain a pleckstrin homology (PH) domain. The PH domain has been shown to interact with phosphatidylinositol 3,4,5-triphosphate and is believed to promote membrane targeting of the cytohesins. Recruitment of the cytohesins to the membranes can occur in response to tyrosine kinase receptor activation. This response appears to require the activation of phosphatidylinositol 3-kinase (PI 3-kinase).Synonyms: ARF exchange factor, ARF nucleotide-binding site opener, ARNO, CYTH2, PH, PSCD2, PSCD2L, SEC7 and coiled-coil domain-containing protein 2

Gen-ID: 9266, 9606

UniProt: Q99418