Peptide ELISA: Antibody detection limit dilution: 1/64000. Western Blot: 0.3-1 μg/mL. Approx 40 kDa band observed in Human Pancreas lysates (calculated MW of 46.0 kDaaccording to NP_006208.1 and 47.0 kDa and NP_001012303.1). Immunohistochemistry on Paraffin Sections: 3 μg/mL. In paraffin embedded Human Pancreas, shows cytoplasmic staining of acinar cels and ofrare cells in the islets of Langerhans. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Konzentration
0.5 mg/mL
Buffer
Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preserative and 0.5 % BSA as stabilizer.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung
Avoid repeated freezing and thawing.
Lagerung
4 °C/-20 °C
Informationen zur Lagerung
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Target
SERPINI2
(serpin Peptidase Inhibitor, Clade I (Pancpin), Member 2 (SERPINI2))
Spi14 antikoerper, MEPI antikoerper, PANCPIN antikoerper, PI14 antikoerper, TSA2004 antikoerper, serpin family I member 2 antikoerper, serpin peptidase inhibitor, clade I (pancpin), member 2 L homeolog antikoerper, serpin peptidase inhibitor, clade I (pancpin), member 2 antikoerper, serine (or cysteine) peptidase inhibitor, clade I, member 2 antikoerper, SERPINI2 antikoerper, serpini2.L antikoerper, Serpini2 antikoerper
Hintergrund
MEP1 is a member of the serine protease inhibitor (serpin) superfamily made up of proteins which play central roles in the regulation of a wide variety of physiological processes, including coagulation, fibrinolysis, development, malignancy and inflammation. It may have a role in a growth-control, possibly growth-suppressing pathway and, when impaired, may be involved in pancreatic carcinogenesis. The protein is a member of the plasminogen activator inhibitor-1 family, a subset of the serpin superfamily whose members act as tissue-specific tPA inhibitors. Two alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene.Synonyms: MEPI, Myoepithelium-derived serine protease inhibitor, PI14, Pancpin, Protease inhibitor 14, TSA2004