TRIM72 Antikörper (C-Term)

Produktnummer ABIN5537808

Produktdetails anti-TRIM72 Antikörper

Target: TRIM72 (Tripartite Motif Containing 72 (TRIM72))

Bindungsspezifität: AA 299-327, C-Term

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TRIM72 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This TRIM72 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 299-327 amino acids from the C-terminal region of human TRIM72.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: For WB starting dilution is: 1:2000

For IHC-P starting dilution is: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.42 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu TRIM72

Target: TRIM72 (Tripartite Motif Containing 72 (TRIM72))

Andere Bezeichnung: TRIM72 (TRIM72 Produkte)

Synonyme: Trim72 antikoerper, MG53 antikoerper, Mg53 antikoerper, BC067209 antikoerper, RGD1562778 antikoerper, tripartite motif containing 72 antikoerper, tripartite motif containing 72, E3 ubiquitin protein ligase L homeolog antikoerper, tripartite motif-containing 72 antikoerper, TRIM72 antikoerper, trim72.L antikoerper, Trim72 antikoerper

Hintergrund: TRIM72 is a muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles (By similarity).

Molekulargewicht: 53 kDa

Gen-ID: 493829

UniProt: Q6ZMU5