GPLD1 Antikörper (C-Term)

Produktnummer ABIN5536185

Produktdetails anti-GPLD1 Antikörper

Target: GPLD1 (Glycosylphosphatidylinositol Specific phospholipase D1 (GPLD1))

Bindungsspezifität: AA 679-709, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GPLD1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Immunogen: This GPLD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 679-709 amino acids from the C-terminal region of human GPLD1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 2 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu GPLD1

Target: GPLD1 (Glycosylphosphatidylinositol Specific phospholipase D1 (GPLD1))

Andere Bezeichnung: GPLD1 (GPLD1 Produkte)

Synonyme: GPIPLD antikoerper, GPIPLDM antikoerper, PIGPLD antikoerper, PIGPLD1 antikoerper, 6330541J12Rik antikoerper, AW546131 antikoerper, glycosylphosphatidylinositol specific phospholipase D1 antikoerper, glycosylphosphatidylinositol specific phospholipase d1 antikoerper, GPLD1 antikoerper, gpld1 antikoerper, Micau_0957 antikoerper, ML5_1205 antikoerper, VAB18032_09490 antikoerper, Gpld1 antikoerper

Hintergrund: GPLD1 is expressed in numerous tissues and cells and specifically cleaves GPI-anchored proteins. Liver has the highest level of GPI-PLD expression and is the primary organ contributing to GPLD1 in the serum. GPLD1 is abundant in serum in which it associates with polipoproteins AI and AIV. Increased serum GPLD1 is associated with insulin resistance and elevated serum triglycerides. Many surface proteins are attached to eukaryotic cell membranes via glycosylphosphatidylinositol (GPI) anchors that are covalently bound to the C-terminus of the protein and cleavage of the GPI moiety by GPLD1, only enzyme known that cleavage GPI anchor, may represent a means of regulating attachment of these proteins to the cell surface, or alternatively, their release into the extracellular environment.

Molekulargewicht: 92 kDa

Gen-ID: 2822

UniProt: P80108

Pathways: Inositol Metabolic Process, Regulation of Carbohydrate Metabolic Process