EGLN3 Antikörper (C-Term)

Produktnummer ABIN5534232

Produktdetails anti-EGLN3 Antikörper

Target: EGLN3 (Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3))

Bindungsspezifität: AA 203-231, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EGLN3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This EGLN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 203-231 amino acids from the C-terminal region of human EGLN3.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu EGLN3

Target: EGLN3 (Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3))

Andere Bezeichnung: EGLN3 (EGLN3 Produkte)

Synonyme: zgc:77019 antikoerper, wu:fj78a08 antikoerper, EGLN3 antikoerper, phd3 antikoerper, PHD-3 antikoerper, PHD3 antikoerper, SM-20 antikoerper, 2610021G09Rik antikoerper, AI505553 antikoerper, AI648162 antikoerper, Hif-p4h-3 antikoerper, Phd3 antikoerper, HIFP4H3 antikoerper, HIFPH3 antikoerper, egl-9 family hypoxia-inducible factor 3 antikoerper, egl-9 family hypoxia inducible factor 3 antikoerper, egl-9 family hypoxia-inducible factor 3 L homeolog antikoerper, egln3 antikoerper, EGLN3 antikoerper, egln3.L antikoerper, Egln3 antikoerper

Hintergrund: EGLN3 catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF-1 alpha at 'Pro-564', and HIF-2 alpha. Functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. May play a role in cell growth regulation in muscle cells and in apoptosis in neuronal tissue. Promotes cell death through a caspase-dependent mechanism (By similarity).

Molekulargewicht: 27 kDa

Gen-ID: 112399

UniProt: Q9H6Z9

Pathways: Positive Regulation of Endopeptidase Activity