PRKG2 Antikörper (C-Term)

Produktnummer ABIN5533945

Produktdetails anti-PRKG2 Antikörper

Target: PRKG2 (Protein Kinase, CGMP-Dependent, Type II (PRKG2))

Bindungsspezifität: AA 714-744, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PRKG2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Immunogen: This cGKII antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 714-744 amino acids from the C-terminal region of human cGKII.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.2 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu PRKG2

Target: PRKG2 (Protein Kinase, CGMP-Dependent, Type II (PRKG2))

Andere Bezeichnung: cGKII (PRKG2 Produkte)

Synonyme: MGC82580 antikoerper, PRKG2 antikoerper, si:dkey-18e17.2 antikoerper, PRKGR2 antikoerper, cGKII antikoerper, GDPKII antikoerper, AW212535 antikoerper, CGKII antikoerper, Prkgr2 antikoerper, cGK-II antikoerper, protein kinase, cGMP-dependent, type II antikoerper, protein kinase, cGMP-dependent, type II L homeolog antikoerper, cGMP-dependent protein kinase 2 antikoerper, PRKG2 antikoerper, prkg2.L antikoerper, prkg2 antikoerper, LOC100541294 antikoerper, Prkg2 antikoerper

Hintergrund: CGKII is thought to play a key role in a diverse set of physiological pathway. cGKII may mediate intestinal secretion of water and electrolytes induced by the E. coli toxin STa and the intestinal peptide guanylin. Edentification of the pathway that mediates intestinal fluid secretion by E. coli STa has potential medical implications because STa causes traveler's diarrhea and about 50 % of infant mortality in developing countries. Transfection experiments in human cells disclose that cGKII phosphorylates SOX9 and attenuates SOX9 function by inhibiting its nuclear entry. Impaired differentiation of cultured KMI chondrocytes can be restored by silencing Sox9 by RNA interference. cGKII is postulated to be a molecular switch that couples the cessation of proliferation and the start of hypertrophic chondrocyte differentiation through attenuating SOX9 function.

Molekulargewicht: 87 kDa

Gen-ID: 5593

UniProt: Q13237