HFE2 Antikörper (C-Term)

Produktnummer ABIN5532574

Produktdetails anti-HFE2 Antikörper

Target: HFE2 (Hemochromatosis Type 2 (Juvenile) (HFE2))

Bindungsspezifität: AA 308-338, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HFE2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS)

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This HFE2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 308-338 amino acids from the C-terminal region of human HFE2.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: For WB starting dilution is: 1:1000

For FACS starting dilution is: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu HFE2

Target: HFE2 (Hemochromatosis Type 2 (Juvenile) (HFE2))

Andere Bezeichnung: HFE2 (HFE2 Produkte)

Synonyme: HFE2A antikoerper, HJV antikoerper, JH antikoerper, RGMC antikoerper, HFE2 antikoerper, DKFZp468F2322 antikoerper, 2310035L15Rik antikoerper, 5230400G09Rik antikoerper, AI414844 antikoerper, AI789733 antikoerper, DL-M antikoerper, Rgmc antikoerper, hemojuvelin antikoerper, RGMr antikoerper, hjv antikoerper, id:ibd3464 antikoerper, wu:fb38f10 antikoerper, zgc:136698 antikoerper, hemochromatosis type 2 (juvenile) antikoerper, hemochromatosis type 2 antikoerper, HFE2 antikoerper, Hfe2 antikoerper, hfe2 antikoerper

Hintergrund: HFE2 is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30.

Molekulargewicht: 45 kDa

Gen-ID: 148738

UniProt: Q6ZVN8

Pathways: Transition Metal Ion Homeostasis