DCC Antikörper (AA 643-670)

Produktnummer ABIN5530998

Produktdetails anti-DCC Antikörper

Target: DCC (Deleted in Colorectal Carcinoma (DCC))

Bindungsspezifität: AA 643-670

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DCC Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This DCC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 643-670 amino acids from the Central region of human DCC.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu DCC

Target: DCC (Deleted in Colorectal Carcinoma (DCC))

Andere Bezeichnung: DCC (DCC Produkte)

Synonyme: CRC18 antikoerper, CRCR1 antikoerper, IGDCC1 antikoerper, MRMV1 antikoerper, DCC antikoerper, zdcc antikoerper, C030036D22Rik antikoerper, Igdcc1 antikoerper, xdcc antikoerper, XDCCa antikoerper, dcca-A antikoerper, Dcc antikoerper, DCC netrin 1 receptor antikoerper, deleted in colorectal carcinoma antikoerper, netrin receptor DCC antikoerper, DCC antikoerper, dcc antikoerper, Dcc antikoerper, LOC100712666 antikoerper

Hintergrund: This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.

Molekulargewicht: 158 kDa

Gen-ID: 1630

UniProt: P43146

Pathways: Regulation of Cell Size