SLAMF7 Antikörper (Middle Region)

Produktnummer ABIN5516380

Produktdetails anti-SLAMF7 Antikörper

Target: SLAMF7 (SLAM Family Member 7 (SLAMF7))

Bindungsspezifität: Middle Region

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SLAMF7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: QNRNRERVDF PDGGYSLKLS KLKKNDSGIY YVGIYSSSLQ QPSTQEYVLH

Aufreinigung: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human SLAMF7

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu SLAMF7

Target: SLAMF7 (SLAM Family Member 7 (SLAMF7))

Andere Bezeichnung: SLAMF7 (SLAMF7 Produkte)

Synonyme: RGD1560190 antikoerper, SLAMF7 antikoerper, slaf7 antikoerper, 19A antikoerper, CD319 antikoerper, CRACC antikoerper, CS1 antikoerper, 19A24 antikoerper, 4930560D03Rik antikoerper, SLAM family member 7 antikoerper, Slamf7 antikoerper, SLAMF7 antikoerper, slaf7 antikoerper

Hintergrund: Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway. Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K. In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells. May play a role in lymphocyte adhesion. In LPS-activated monocytes negatively regulates production of proinflammatory cytokines.

Alias Symbols: 19A, CS1, CD319, CRACC

Protein Size: 296

Gen-ID: 57823

NCBI Accession: NM_001282588, NP_067004