DDIT4 Antikörper (N-Term)

Produktnummer ABIN5516240

Produktdetails anti-DDIT4 Antikörper

Target: DDIT4 (DNA-Damage-Inducible Transcript 4 (DDIT4))

Bindungsspezifität: N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DDIT4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: LWDRFSSSST SSSPSSLPRT PTPDRPPRSA WGSATREEGF DRSTSLESSD

Aufreinigung: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human DDIT4

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu DDIT4

Target: DDIT4 (DNA-Damage-Inducible Transcript 4 (DDIT4))

Andere Bezeichnung: DDIT4 (DDIT4 Produkte)

Synonyme: redd1 antikoerper, Dig2 antikoerper, REDD-1 antikoerper, REDD1 antikoerper, 5830413E08Rik antikoerper, AA415483 antikoerper, Rtp801 antikoerper, dig2 antikoerper, rtp801 antikoerper, sb:cb821 antikoerper, zgc:64114 antikoerper, DNA damage inducible transcript 4 antikoerper, DNA-damage-inducible transcript 4 antikoerper, DNA damage inducible transcript 4 S homeolog antikoerper, ddit4 antikoerper, DDIT4 antikoerper, Ddit4 antikoerper, ddit4.S antikoerper

Hintergrund: Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type, it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes (By similarity). Required for mTORC1-mediated defense against viral protein synthesis and virus replication (By similarity). Inhibits neuronal differentiation and neurite outgrowth mediated by NGF via its effect on mTORC1 activity. Required for normal neuron migration during embryonic brain development. Plays a role in neuronal cell death.

Alias Symbols: Dig2, REDD1, REDD-1

Protein Size: 232

Gen-ID: 54541

NCBI Accession: NM_019058, NP_061931

UniProt: Q9NX09

Pathways: Neurotrophin Signalübertragung, Regulation of Carbohydrate Metabolic Process