PDE6A Antikörper (Middle Region)

Produktnummer ABIN5516136

Produktdetails anti-PDE6A Antikörper

Target: PDE6A (phosphodiesterase 6A, CGMP-Specific, Rod, alpha (PDE6A))

Bindungsspezifität: Middle Region

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PDE6A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: YTVRAFLNCD RYSVGLLDMT KQKEFFDVWP VLMGEVPPYS GPRTPDGREI

Aufreinigung: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PDE6A

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu PDE6A

Target: PDE6A (phosphodiesterase 6A, CGMP-Specific, Rod, alpha (PDE6A))

Andere Bezeichnung: PDE6A (PDE6A Produkte)

Synonyme: si:bz1d10.3 antikoerper, si:rp71-1d10.3 antikoerper, CGPR-A antikoerper, PDEA antikoerper, RP43 antikoerper, Pdea antikoerper, nmf282 antikoerper, phosphodiesterase 6A, cGMP-specific, rod, alpha antikoerper, phosphodiesterase 6A antikoerper, pde6a antikoerper, PDE6A antikoerper, Pde6a antikoerper

Hintergrund: This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa.

Alias Symbols: PDEA, RP43, CGPR-A

Protein Size: 167

Gen-ID: 5145

NCBI Accession: NM_000440, NP_000431

UniProt: P16499

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction