MAP3K7 Antikörper (C-Term)

Produktnummer ABIN5516090

Der Kaninchen Polyklonal anti-MAP3K7 Antikörper (ABIN5516090) detektiert spezifisch MAP3K7 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für MAP3K7 Antikörper (C-Term) (ABIN5516090)

Target: MAP3K7 (Mitogen-Activated Protein Kinase Kinase Kinase 7 (MAP3K7))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAP3K7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-MAP3K7 Antikörper

Bindungsspezifität: C-Term

Sequenz: VTGTEPGQVS SRSSSPSVRM ITTSGPTSEK PTRSHPWTPD DSTDTNGSDN

Produktmerkmale: This is a rabbit polyclonal antibody against MAP3K7. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human MAP3K7

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu MAP3K7

Target: MAP3K7 (Mitogen-Activated Protein Kinase Kinase Kinase 7 (MAP3K7))

Andere Bezeichnung: MAP3K7

Hintergrund: The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2, this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

Alias Symbols: MAP3K7, TAK1,

Protein Interaction Partner: MAGED1, UBC, TRAF6, HSPB1, TAB2, IKBKB, TRAF4, TGFBR1, MAP3K7, MAP2K6, MAPK8, NAIP, XIAP, RIPK1, TIRAP, TAB1, SIK1, SIK3, SYK, SASH1, IRAK1, TNFRSF1A, MAPK8IP1, RIPK2, IKBKG, VRK2, MAP2K4, NOD2, PRKCQ, PPM1L, SKIL, PPP6C, PPP2R1A, MAP3K3, BST2, PINK1, MAL

Protein Size: 579

Gen-ID: 6885

Pathways: NF-kappaB Signalweg, T-Zell Rezeptor Signalweg, TLR Signalweg, Fc-epsilon Rezeptor Signalübertragung, Activation of Innate immune Response, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Toll-Like Receptors Cascades, BCR Signaling, Ubiquitin Proteasome Pathway