Importin 5 Antikörper (N-Term)

Produktnummer ABIN5515624

Produktdetails anti-Importin 5 Antikörper

Target: Importin 5 (IPO5)

Bindungsspezifität: N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Importin 5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: EDEDWANADE LEDDDFDSNA VAGESALDRM ACGLGGKLVL PMIKEHIMQM

Produktmerkmale: This is a rabbit polyclonal antibody against IPO5. It was validated on Western Blot.

Aufreinigung: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human IPO5

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu Importin 5

Target: Importin 5 (IPO5)

Andere Bezeichnung: IPO5 (IPO5 Produkte)

Synonyme: IPO5 antikoerper, RANBP5 antikoerper, IMB3 antikoerper, KPNB3 antikoerper, Pse1 antikoerper, imp5 antikoerper, 1110011C18Rik antikoerper, 5730478E03Rik antikoerper, AA409333 antikoerper, C76941 antikoerper, Kpnb3 antikoerper, Ranbp5 antikoerper, importin 5 antikoerper, IPO5 antikoerper, Ipo5 antikoerper

Hintergrund: Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family.

Alias Symbols: IPO5, KPNB3, RANBP5,

Protein Interaction Partner: HUWE1, UBC, STAU1, ASB15, HK2, HEXB, ATIC, MCTS1, TNFAIP8, EZR, UBA1, TXNRD1, FBXO6, BHLHB9, EGFR, MUC1, SOX2, NPM1, HDAC2, LAS1L, PELP1, WASL, VCAM1, MAP1LC3A, ITGA4, FN1, CFTR, RPL7, CA9, NOTCH1, IPO4, TNPO1, KPNB1, RAN, CUL3, ACD, TINF2, TERF1, BKRF1,

Protein Size: 1097

Gen-ID: 3843

UniProt: O00410

Pathways: Protein targeting to Nucleus