Calpain 6 Antikörper (Middle Region)

Produktnummer ABIN5514668

Produktdetails anti-Calpain 6 Antikörper

Target: Calpain 6 (CAPN6)

Bindungsspezifität: Middle Region

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Calpain 6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: TIPNHKEQEW DPQKTEKYAG IFHFRFWHFG EWTEVVIDDL LPTINGDLVF

Aufreinigung: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CAPN6

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu Calpain 6

Target: Calpain 6 (CAPN6)

Andere Bezeichnung: CAPN6 (CAPN6 Produkte)

Synonyme: CAPN6 antikoerper, CANPX antikoerper, CAPNX antikoerper, CalpM antikoerper, DJ914P14.1 antikoerper, calpain 6 antikoerper, CAPN6 antikoerper, Capn6 antikoerper

Hintergrund: Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is highly expressed in the placenta. Its C-terminal region lacks any homology to the calmodulin-like domain of other calpains. The protein lacks critical active site residues and thus is suggested to be proteolytically inactive. The protein may play a role in tumor formation by inhibiting apoptosis and promoting angiogenesis.

Alias Symbols: CANPX, CAPNX, CalpM, DJ914P14.1

Protein Size: 641

Gen-ID: 827

NCBI Accession: NM_014289, NP_055104

UniProt: Q9Y6Q1