IRS1 Antikörper (pSer307)

Produktnummer ABIN538222

Produktdetails anti-IRS1 Antikörper

Target: IRS1 (Insulin Receptor Substrate 1 (IRS1))

Bindungsspezifität: pSer307

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IRS1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Verwendungszweck: Rabbit polyclonal antibody raised against synthetic phosphopeptide of IRS1.

Spezifität: Reactivity occurs against human IRS1 pS307 protein and This antibody is specific to the phosphorylated form of the protein. Reactivity with non-phosphorylated human IRS1 is minimal by ELISA.

Kreuzreaktivität: Huhn, Rind (Kuh), Hund, Human, Affe, Maus, Schwein, Ratte

Produktmerkmale: Antibody Reactive Against Synthetic Peptide.

Immunogen: Synthetic phosphopeptide corresponding to residues surrounding S307 of human IRS1.

Anwendungsinformationen

Applikationshinweise: ELISA (1:2000-1:10000)
Western Blot (1:250-1:1500)
The optimal working dilution should be determined by the end user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 20 mM KH₂PO₄, 150 mM NaCl, pH 7.2 (0.01 % sodium azide)

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.

Referenzen für anti-IRS1 Antikörper (ABIN538222)

Danielsson, Ost, Nystrom, Strålfors: "Attenuation of insulin-stimulated insulin receptor substrate-1 serine 307 phosphorylation in insulin resistance of type 2 diabetes." in: The Journal of biological chemistry, Vol. 280, Issue 41, pp. 34389-92, (2005) (PubMed).

Andreozzi, DAlessandris, Federici, Laratta, Del Guerra, Del Prato, Marchetti, Lauro, Perticone, Sesti et al.: "Activation of the hexosamine pathway leads to phosphorylation of insulin receptor substrate-1 on Ser307 and Ser612 and impairs the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin ..." in: Endocrinology, Vol. 145, Issue 6, pp. 2845-57, (2004) (PubMed).

Jiang, Dallas-Yang, Liu, Moller, Zhang et al.: "Salicylic acid reverses phorbol 12-myristate-13-acetate (PMA)- and tumor necrosis factor alpha (TNFalpha)-induced insulin receptor substrate 1 (IRS1) serine 307 phosphorylation and insulin resistance ..." in: The Journal of biological chemistry, Vol. 278, Issue 1, pp. 180-6, (2002) (PubMed).

Details zu IRS1

Target: IRS1 (Insulin Receptor Substrate 1 (IRS1))

Andere Bezeichnung: IRS1 (IRS1 Produkte)

Synonyme: HIRS-1 antikoerper, G972R antikoerper, IRS-1 antikoerper, IRS1IRM antikoerper, irs1 antikoerper, irsu antikoerper, IRS1 antikoerper, irs-1 antikoerper, irs1-a antikoerper, insulin receptor substrate 1 antikoerper, insulin receptor substrate 2 antikoerper, insulin receptor substrate 1 S homeolog antikoerper, IRS1 antikoerper, Irs1 antikoerper, irs2 antikoerper, irs1.S antikoerper

Gen-ID: 3667

Pathways: Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Positive Regulation of Peptide Hormone Secretion, Hormone Transport, Negative Regulation of Hormone Secretion, Response to Growth Hormone Stimulus, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process