TBPL1 Antikörper

Produktnummer ABIN5027797

Produktdetails anti-TBPL1 Antikörper

Target: TBPL1 (TBP-Like 1 (TBPL1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TBPL1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Aufreinigung: Protein G Chromatography

Immunogen: Full length recombinant TRF2 protein was used as the immunogen for this antibody.

Klon: ABM10H3

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: WB: 2-4 μg/mL, IHC: 5 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Details zu TBPL1

Target: TBPL1 (TBP-Like 1 (TBPL1))

Andere Bezeichnung: TRF2 (TBPL1 Produkte)

Synonyme: MGC:8389 antikoerper, MGC:9620 antikoerper, STUD antikoerper, TLF antikoerper, TLP antikoerper, TRF2 antikoerper, tlf antikoerper, 4732475G08 antikoerper, AW011832 antikoerper, AW491032 antikoerper, D18347 antikoerper, STD antikoerper, TRP antikoerper, Tlp antikoerper, tlp antikoerper, trf antikoerper, trf2 antikoerper, trp antikoerper, zgc:92340 antikoerper, TATA binding protein 1 antikoerper, TFIID-1 antikoerper, TRANSCRIPTION FACTOR IID-1 antikoerper, TATA-box binding protein like 1 antikoerper, TATA-binding protein 1 antikoerper, TATA-box binding protein like 1 L homeolog antikoerper, TATA box binding protein-like 1 antikoerper, TBP-like 1 antikoerper, TATA binding protein 1 antikoerper, TBPL1 antikoerper, tbp1 antikoerper, tbpl1.L antikoerper, tbpl1 antikoerper, Tbpl1 antikoerper, TBP1 antikoerper

Hintergrund: TRF2 (Telomere Repeat Binding Factor 2), a subunit of the shelterin complex, binds to duplex telomeric DNA and plays a crucial role in telomere protection. TRF2 contains an N-terminal basic domain rich in glycines and arginines (the GAR domain), a central TRFH dimerization domain, a flexible linker region and a C-terminal Myb-like DNA binding domain. TRF2 undergoes extensive post-translational modification, which in turn regulates its stability, DNA binding and cellular localization. Ubiquitylation of TRF2 by Siah1, an E3 ligase, promotes TRF2 degradation and replicative senescence of human primary fibroblasts. TRF2 is phosphorylated in response to DNA damage and this phosphorylation has been implicated in DNA double strand break repair.

Molekulargewicht: 50 kDa

Gen-ID: 7014

UniProt: Q15554