BST2 Antikörper

Produktnummer ABIN5027752

Produktdetails anti-BST2 Antikörper

Target: BST2 (Bone Marrow Stromal Cell Antigen 2 (BST2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser BST2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS)

Aufreinigung: Protein G Chromatography

Immunogen: Full length recombinant protein of BST 2 was used as the immunogen for this antibody.

Klon: ABM52D8

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: WB: 2-4 μg/mL, FACS: 0.5-1 μg/10^6

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Details zu BST2

Target: BST2 (Bone Marrow Stromal Cell Antigen 2 (BST2))

Andere Bezeichnung: BST 2 (BST2 Produkte)

Synonyme: BST2 antikoerper, CD317 antikoerper, TETHERIN antikoerper, 2310015I10Rik antikoerper, Bst-2 antikoerper, C87040 antikoerper, DAMP-1 antikoerper, GREG antikoerper, Damp1 antikoerper, bone marrow stromal cell antigen 2 antikoerper, bone marrow stromal antigen 2 antikoerper, BST2 antikoerper, LOC618737 antikoerper, Bst2 antikoerper

Hintergrund: BST2 (Bone Marrow Stromal Antigen 2), a type II transmembrane protein also known as HM1.24/CD317, has been identified to be overexpressed in a variety of cell lines from different cancer types, including multiple myeloma, breast, lung, and kidney cancers. BST2 was discovered as a marker of differentiated B cells and was later rediscovered as a potent antiviral restriction factor with the ability to tether enveloped viruses to the cell membrane of infected cells via its GPI anchor as well as to potently inhibit virus replication in cultured cells and in vivo. It also acts as an innate immune sensor of HIV-1 that elicits an inflammatory response upon exposure. BST2 mediate host immune response by activating NF-KB through interaction with TAK1 (Transforming Growth Factor Beta-Activated Kinase 1) and TNF receptor associated factors (TRAFs) 2 and 6. In addition, BST2 induces ADCC (antibody-dependent cell cytotoxicity) against the envelope protein of HIV. BST2 was expressed constitutively on the cell surface of both CD3- and CD3+ thymocytes ex vivo.

Molekulargewicht: 17 kDa

Gen-ID: 684

UniProt: Q10589

Pathways: Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response