PTH Antikörper (AA 1-236)

Produktnummer ABIN5027427

Produktdetails anti-PTH Antikörper

Target: PTH (Parathyroid Hormone (PTH))

Bindungsspezifität: AA 1-236

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PTH Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Western Blotting (WB)

Aufreinigung: Protein G Chromatography

Immunogen: A partial length recombinant Parathyroid Hormone protein (amino acids 1-236) was used as the immunogen for this antibody

Klon: ABM4D44

Isotyp: IgG2b kappa

Anwendungsinformationen

Applikationshinweise: WB: 2-4 μg/mL, IHC: 5 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Details zu PTH

Target: PTH (Parathyroid Hormone (PTH))

Andere Bezeichnung: Parathyroid Hormone (PTH Produkte)

Synonyme: PTH1 antikoerper, Pthp antikoerper, PTH-(1-84) antikoerper, Pth1 antikoerper, Pthr1 antikoerper, PTH antikoerper, parathyroid hormone antikoerper, parathyroid hormone S homeolog antikoerper, PTH antikoerper, Pth antikoerper, pth.S antikoerper

Substanzklasse: Hormone

Hintergrund: Parathyroid hormone (PTH) produced and secreted by parathyroid glands, maintains mineral homeostasis by regulating calcium and phosphate absorption/reabsorption. It modulates phosphate homeostasis by downregulating Dentin matrix acidic phosphoprotein 1(DMP1) expression via the cAMP/PKA pathway targeting genes/proteins mutually governed by PTH. PTH secretion is characterized by an ultradian rhythm with tonic and pulsatile components. The majority of PTH is secreted in tonic fashion. Changes in the ultradian PTH secretion are correlated with skeletal fragility in primary and secondary osteoporosis. Plasma concentrations of Zn ions levels were significantly correlated with PTH levels. PTH in serum is typical for patients with chronic kidney disease (CKD). The onset of CKD is associated with pathway changes of protein synthesis and metabolism, amino acid metabolism, energy metabolism, and steroid hormone metabolism. Parathyroid hormones are bone-forming agents that have different modes of action on the bone. Lack of PTH in the central nervous system causes Hypoparathyroidism (HPT).

Molekulargewicht: 59 kDa

Gen-ID: 5745

UniProt: Q03431

Pathways: cAMP Metabolic Process, Regulation of Carbohydrate Metabolic Process