SOX2 Antikörper
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- Target Alle SOX2 Antikörper anzeigen
- SOX2 (SRY (Sex Determining Region Y)-Box 2 (SOX2))
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser SOX2 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Aufreinigung
- Protein A Chromatography
- Immunogen
- A full length recombinant Sox2 protein was used as the immunogen for this antibody.
- Isotyp
- IgG
- Top Product
- Discover our top product SOX2 Primärantikörper
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- Applikationshinweise
- WB: 1-2 μg/mL
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 0.5 mg/mL
- Buffer
- PBS containing 0.05 % BSA, PH 7.4
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
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- Target
- SOX2 (SRY (Sex Determining Region Y)-Box 2 (SOX2))
- Andere Bezeichnung
- SOX2 (SOX2 Produkte)
- Synonyme
- ANOP3 antikoerper, MCOPS3 antikoerper, RGD1565646 antikoerper, Sox-2 antikoerper, lcc antikoerper, ysb antikoerper, cb236 antikoerper, wu:fb83g04 antikoerper, wu:fc14d07 antikoerper, zgc:65860 antikoerper, zgc:77389 antikoerper, SRY-box2 antikoerper, Xsox-2 antikoerper, anop3 antikoerper, mcops3 antikoerper, sox-2 antikoerper, SRY-box 2 antikoerper, SRY box 2 antikoerper, SRY (sex determining region Y)-box 2 antikoerper, SRY-box 2 S homeolog antikoerper, SOX2 antikoerper, Sox2 antikoerper, sox2 antikoerper, sox2.S antikoerper
- Hintergrund
- SOX2 is a member of the SRY-related HMG-box (SOX) transcription factor family with a set of well-established and diverse roles in stem cell potency and maintenance, embryonic development and cancer. It regulates extensive and often divergent transcriptional networks across different cell types. SOX2 is best known as a core pluripotency factor, maintaining the undifferentiated phenotype of pluripotent stem cells, and is closely co-regulated alongside core pluripotency factors OCT4 and NANOG in undifferentiated ESCs (Embryonic Stem Cells), ECCs (Embryonal Carcinoma Cells) and iPSCs (Induced Pluripotent Stem Cells). Loss of SOX2 expression in these cell lines triggers their differentiation. More recently, SOX2 has been identified as a crucial player in the maintenance and differentiation of adult stem cells such as in neural stem cells. Moreover, high expression levels of SOX2 correlate with tumor progression or poor prognosis of multiple cancers. In contrast, the tumor-suppressive role of SOX2 has been reported in gastric cancer and squamous cell lung cancer.
- Molekulargewicht
- 34 kDa
- Gen-ID
- 6657
- UniProt
- P48431
- Pathways
- Dopaminergic Neurogenesis, Sensory Perception of Sound, Stem Cell Maintenance, Cell RedoxHomeostasis
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