FEZF1 Antikörper (AA 199-280) (Alexa Fluor 680)

Produktnummer ABIN5012724

Produktdetails anti-FEZF1 Antikörper (Alexa Fluor 680)

Target: FEZF1 (FEZ Family Zinc Finger 1 (FEZF1))

Bindungsspezifität: AA 199-280

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FEZF1 Antikörper ist konjugiert mit Alexa Fluor 680

Applikation: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Homologie: Human,Mouse,Rat,Cow,Sheep,Pig,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ZNF312B

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu FEZF1

Target: FEZF1 (FEZ Family Zinc Finger 1 (FEZF1))

Andere Bezeichnung: ZNF312B/FEZF1 (FEZF1 Produkte)

Synonyme: RGD1560480 antikoerper, fezf antikoerper, znf312b antikoerper, MGC145310 antikoerper, FEZ antikoerper, ZNF312B antikoerper, 3110069A13Rik antikoerper, Fez antikoerper, Zfp312-like antikoerper, fez-like antikoerper, fez antikoerper, fezf2 antikoerper, wu:fc29c05 antikoerper, wu:fc89h05 antikoerper, zgc:153730 antikoerper, Fez family zinc finger 1 antikoerper, FEZ family zinc finger 1 antikoerper, Fez family zinc finger protein 1 antikoerper, FEZ family zinc finger 1 S homeolog antikoerper, Fezf1 antikoerper, FEZF1 antikoerper, fezf1 antikoerper, Tsp_12536a antikoerper, Tsp_12536 antikoerper, fezf1.S antikoerper

Hintergrund:

Synonyms: FEZ, FEZ family zinc finger 1, Fez family zinc finger protein 1, fez like, fezf1, FEZF1_HUMAN, Zinc finger protein 312 like, Zinc finger protein 312B.

Background: Olfactory sensory neurons contain olfactory receptors, which are G protein-coupled receptor proteins that localize to the cilia and display affinity for and bind to a variety of odor molecules. Olfactory neurons send their axons from the olfactory epithelium to the olfactory bulb, which is covered by the CNS basal lamina. FEZF1 (Fez family zinc finger protein 1), also known as Forebrain Embryonic Zinc Finger and Zinc finger protein 312B, is a 475 amino acid nuclear protein that is expressed in the olfactory epithelium and hypothalamus of mice. In FEZF1-deficient mice, axons of olfactory neurons do not reach the olfactory bulb, suggesting that FEXF1 is required for the penetration of olfactory axons though the basal lamina before innervation of the olfactory bulb. When FEZF1 translocates to the nucleus, it induces KRAS overexpression, resulting in activation of ERK-signaling. Overexpression of FEZF1 leads to accelerated proliferation in cultured cells and increased tumor mass in mice. There are three isoforms of FEZF1 that are produced as a result of alternative splicing events.