MUL1 Antikörper (AA 45-95) (Alexa Fluor 680)

Produktnummer ABIN5001654

Produktdetails anti-MUL1 Antikörper (Alexa Fluor 680)

Target: MUL1 (Mitochondrial E3 Ubiquitin Protein Ligase 1 (MUL1))

Bindungsspezifität: AA 45-95

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MUL1 Antikörper ist konjugiert mit Alexa Fluor 680

Applikation: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human E3 ubiquitin ligase/RNF218

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu MUL1

Target: MUL1 (Mitochondrial E3 Ubiquitin Protein Ligase 1 (MUL1))

Andere Bezeichnung: E3 ubiquitin ligase (MUL1 Produkte)

Synonyme: C1orf166 antikoerper, GIDE antikoerper, MAPL antikoerper, MULAN antikoerper, RNF218 antikoerper, RP11-401M16.2 antikoerper, mul1 antikoerper, zgc:92166 antikoerper, 0610009K11Rik antikoerper, AV000801 antikoerper, Gide antikoerper, RGD1309944 antikoerper, im:7146383 antikoerper, zgc:165594 antikoerper, mitochondrial E3 ubiquitin protein ligase 1 antikoerper, mitochondrial E3 ubiquitin protein ligase 1 L homeolog antikoerper, mitochondrial E3 ubiquitin protein ligase 1a antikoerper, mitochondrial ubiquitin ligase activator of NFKB 1 antikoerper, mitochondrial E3 ubiquitin protein ligase 1b antikoerper, MUL1 antikoerper, mul1.L antikoerper, mul1a antikoerper, Mul1 antikoerper, mul1b antikoerper

Hintergrund:

Synonyms: GIDE, MAPL, MULAN, RNF218, C1orf166, Mitochondrial ubiquitin ligase activator of NFKB 1, E3 SUMO-protein ligase MUL1, E3 ubiquitin-protein ligase MUL1, Growth inhibition and death E3 ligase, Mitochondrial-anchored protein ligase, Putative NF-kappa-B-activating protein 266, RING finger protein 218, MUL1

Background: Exhibits weak E3 ubiquitin-protein ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteosomal degradation. Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations. Plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. The function may implicate its abilty to sumoylate DNM1L. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. Involved in the modulation of innate immune defense against viruses by inhibiting DDX58-dependent antiviral response. Can mediate DDX58 sumoylation and disrupt its polyubiquitination.

Gen-ID: 79594

UniProt: Q969V5

Pathways: Positive Regulation of Endopeptidase Activity