CBLN2 Antikörper (AA 151-224) (Alexa Fluor 750)

Produktnummer ABIN4999169

Produktdetails anti-CBLN2 Antikörper (Alexa Fluor 750)

Target: CBLN2 (Cerebellin 2 Precursor (CBLN2))

Bindungsspezifität: AA 151-224

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CBLN2 Antikörper ist konjugiert mit Alexa Fluor 750

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Ratte

Homologie: Human,Mouse,Dog,Cow,Pig,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CBLN2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu CBLN2

Target: CBLN2 (Cerebellin 2 Precursor (CBLN2))

Andere Bezeichnung: CBLN2 (CBLN2 Produkte)

Synonyme: MGC64397 antikoerper, si:dkey-82k12.11 antikoerper, 6330593N19Rik antikoerper, A730004O05 antikoerper, zgc:163051 antikoerper, cerebellin 2 precursor antikoerper, cerebellin 2 precursor L homeolog antikoerper, cerebellin 2a precursor antikoerper, cerebellin 2 precursor protein antikoerper, cerebellin 2b precursor antikoerper, CBLN2 antikoerper, cbln2.L antikoerper, cbln2 antikoerper, cbln2a antikoerper, Cbln2 antikoerper, cbln2b antikoerper

Hintergrund:

Synonyms: A730004O05, Cbln2, CBLN2_HUMAN, Cerebellin 2, Cerebellin 2 precursor, Cerebellin-2, OTTHUMP00000163726.

Background: Cerebellin (CER), which was originally isolated from rat cerebellum, is a hexadecapeptide derived from a larger precursor Cerebellin 1, also designated precerebellin 1 or Cbln1. Four propeptides, Cerebellin 1, Cerebellin 2 (Cbln2), Cerebellin 3 (Cbln3), and Cerebellin 4 (Cbln4), comprise the precerebellin subfamily within the C1q protein family. Cerebellin family members act as transneuronal regulators of synapse development and synaptic plasticity in various brain regions. CER and it metabolite des-Ser1-cerebellin are also expressed in several extra-cerebellar tissues, including adrenal gland. Cerebellin 1, 2 and 3 assemble into homomeric and heteromeric complexes, thereby influencing each other?s degradation and secretion. Cerebellin 3 is not able to form homomeric complexes, and can only be secreted upon forming a heteromeric complex with Cerebellin 1. Decreased concentrations of CER has been found in the brain of patients with olivopontocerebellar atrophy (OPCA) and Shy-Drager syndrome, suggesting a role for CER in the pathology of these diseases.