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NMDA 1 Receptor Antikörper (pSer896)

NMDA R1 Reaktivität: Human, Ratte, Maus IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN498858
  • Target Alle NMDA 1 Receptor (NMDA R1) Antikörper anzeigen
    NMDA 1 Receptor (NMDA R1) (NMDA Receptor 1 (NMDA R1))
    Bindungsspezifität
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer896
    Reaktivität
    • 19
    • 16
    • 15
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Ratte, Maus
    Wirt
    • 18
    • 5
    Kaninchen
    Klonalität
    • 18
    • 5
    Polyklonal
    Konjugat
    • 23
    Dieser NMDA 1 Receptor Antikörper ist unkonjugiert
    Applikation
    • 19
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Spezifität
    This antibody detects endogenous levels of p-NMDAR1 protein. (region surrounding Ser896)
    Kreuzreaktivität (Details)
    Species reactivity (expected):Mouse and Rat.
    Species reactivity (tested):Human.
    Aufreinigung
    Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
    Reinheit
    > 95 % (by SDS-PAGE)
    Top Product
    Discover our top product NMDA R1 Primärantikörper
  • Applikationshinweise
    Immunohistochemistry on paraffin sections: 1: 50 - 1: 200.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.2, 0.05 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Target
    NMDA 1 Receptor (NMDA R1) (NMDA Receptor 1 (NMDA R1))
    Andere Bezeichnung
    NMDA Receptor 1 (NMDA R1 Produkte)
    Synonyme
    CG2902 antikoerper, DMNMDAR1 antikoerper, DNMDAR-I antikoerper, DNmdar antikoerper, DmelNmdar1 antikoerper, Dmel\\CG2902 antikoerper, DrNR1 antikoerper, NMDA antikoerper, NMDA R1 antikoerper, NMDAR1 antikoerper, NMdar1 antikoerper, NR1 antikoerper, NRI antikoerper, Nmdar antikoerper, dNR1 antikoerper, dnmdar-I antikoerper, nmr antikoerper, NMDA receptor 1 antikoerper, Nmdar1 antikoerper
    Hintergrund
    NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors. The ion channels activated by glutamate are divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by kainate and a-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as kainate/AMPA receptors (K/AMPAR). NMDA receptors are among the most studied receptors in neuroscience because they are involved in neuronal cell development and plasticity, a cellular correlate for learning. NMDA receptors are also implicated in several disorders of the central nervous sytem including epilepsy and ischemic neuronal cell death. NMDA receptors also appear to be a target for ethanol at physiological concentrations and therefore may play a significant role in alcoholism.Synonyms: GRIN1, Glutamate [NMDA] receptor subunit zeta-1, NMDAR1
    Molekulargewicht
    approx. 120 kDa
    Gen-ID
    2902
    NCBI Accession
    NP_000823
    UniProt
    Q05586
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