DAB1 Antikörper

Produktnummer ABIN498640

Produktdetails anti-DAB1 Antikörper

Target: DAB1 (Disabled Homolog 1 (Drosophila) (DAB1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DAB1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Spezifität: This antibody detects endogenous levels of Dab1 protein. (region surrounding Gln226)

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: Affinity chromatography

Reinheit: > 95 % by SDS-PAGE

Anwendungsinformationen

Applikationshinweise: Western Blot: 1/500 - 1/1000. Immunofluorescence: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu DAB1

Target: DAB1 (Disabled Homolog 1 (Drosophila) (DAB1))

Andere Bezeichnung: DAB1 (DAB1 Produkte)

Synonyme: AI956902 antikoerper, C630028C02Rik antikoerper, scm antikoerper, scr antikoerper, scrambler antikoerper, yot antikoerper, disabled-1 antikoerper, LOC100232823 antikoerper, si:dkey-242m13.1 antikoerper, DAB1 antikoerper, zgc:136547 antikoerper, DAB1, reelin adaptor protein antikoerper, disabled 1 antikoerper, disabled homolog 1 antikoerper, Dab, reelin signal transducer, homolog 1a (Drosophila) antikoerper, Dab, reelin signal transducer, homolog 1b (Drosophila) antikoerper, DAB1 antikoerper, Dab1 antikoerper, LOC100232823 antikoerper, dab1a antikoerper, dab1b antikoerper

Hintergrund: Dab1, a homolog of the Drosophila Disabled protein, is an adaptor protein involved in neural development. This cytoplasmic protein is tyrosine-phosphorylated during rapid expansion of the developing nervous system, and it is thought to interact with other proteins via a domain similar to the PTB domains of the Shc family. Dab1 has been shown to interact with the SH2 domains of Src, Fyn and Abl. Mutations in Dab1 result in widespread abnormalities in the brain, similar to those seen in Reelin mutants. Reelin is a secreted protein thought to play a role in directing migrating neurons. Evidence suggests that Dab1 functions downstream of Reelin in a signaling pathway involved in positioning cells in the developing brain. Dab2 (also designated DOC-2) is a mitogen-responsive phosphoprotein that binds the SH3 domain of Grb2, and it is thought to be a negative regulator of growth.Synonyms: Disabled homolog 1

Molekulargewicht: approx. 60 kDa

Gen-ID: 1600

NCBI Accession: NP_066566

UniProt: O75553