SMAD6 Antikörper

Produktnummer ABIN498566

Produktdetails anti-SMAD6 Antikörper

Target: SMAD6 (SMAD, Mothers Against DPP Homolog 6 (SMAD6))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SMAD6 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody detects endogenous levels of Smad6 protein. (region surrounding asn372)

Kreuzreaktivität (Details): Species reactivity (tested):Human, Mouse.

Aufreinigung: Affinity chromatography

Reinheit: > 95 % by SDS-PAGE

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu SMAD6

Target: SMAD6 (SMAD, Mothers Against DPP Homolog 6 (SMAD6))

Andere Bezeichnung: SMAD6 (SMAD6 Produkte)

Synonyme: madh6 antikoerper, madh7 antikoerper, Xsmad6 antikoerper, hst17432 antikoerper, AOVD2 antikoerper, HsT17432 antikoerper, MADH6 antikoerper, MADH7 antikoerper, Madh6 antikoerper, b2b390Clo antikoerper, Smad6-like antikoerper, smad6 antikoerper, wu:fb22g05 antikoerper, SMAD family member 6 antikoerper, SMAD family member 6a antikoerper, smad6 antikoerper, SMAD6 antikoerper, Smad6 antikoerper, smad6a antikoerper

Hintergrund: Smad proteins, the mammalian homologs of the Drosophila Mothers against dpp (Mad) have been implicated as downstream effectors of TGFbeta/BMP signaling. Smad1 (also designated Madr1 or JV4-1), Smad5 and mammalian Smad8 (also designated Smad9 or MadH6) are effectors of BMP2 and BMP4 function, while Smad2 (also designated Madr2 or JV18-1) and Smad3 are involved in TGFbeta and activinmediated growth modulation. Smad4 (also designated DPC4) has been shown to mediate all of the above activities through interaction with various Smad family members. Smad6 and Smad7 regulate the response to activin/TGFbeta signaling by interfering with TGFbeta-mediated phosphorylation of other Smad family members.Synonyms: MAD homolog 6, MADH6, Mothers against DPP homolog 6, Mothers against decapentaplegic homolog 6, SMAD 6, SMAD family member 6, SMAD-6

Molekulargewicht: approx. 53 kDa

Gen-ID: 4091

NCBI Accession: NP_001136333

UniProt: O43541

Pathways: Chromatin Binding