MEIS1 Antikörper

Produktnummer ABIN498509

Produktdetails anti-MEIS1 Antikörper

Target: MEIS1 (Meis Homeobox 1 (MEIS1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MEIS1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: This antibody detects endogenous levels of Meis1 protein. (region surrounding Ile278)

Kreuzreaktivität (Details): Species reactivity (tested):Human, Mouse.

Aufreinigung: Affinity chromatography

Reinheit: > 95 % by SDS-PAGE

Anwendungsinformationen

Applikationshinweise: Western Blot: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu MEIS1

Target: MEIS1 (Meis Homeobox 1 (MEIS1))

Andere Bezeichnung: MEIS1 (MEIS1 Produkte)

Synonyme: meis antikoerper, 1323/07 antikoerper, 1422/04 antikoerper, CG17117 antikoerper, Dm-HTH antikoerper, Dmel\\CG17117 antikoerper, HTH antikoerper, Hth antikoerper, Meis1 antikoerper, P53 antikoerper, anon-EST:Liang-2.13 antikoerper, clone 2.13 antikoerper, dtl antikoerper, hth1 antikoerper, hth2 antikoerper, l(3)05745 antikoerper, l(3)86Ca antikoerper, cb224 antikoerper, id:ibd5078 antikoerper, meis1.1 antikoerper, wu:fb38b03 antikoerper, wu:fc02e11 antikoerper, wu:fd12a02 antikoerper, C530044H18Rik antikoerper, Evi8 antikoerper, Meis homeobox 1 antikoerper, Meis homeobox 1 S homeolog antikoerper, homothorax antikoerper, Meis homeobox 1 b antikoerper, MEIS1 antikoerper, meis1.S antikoerper, Meis1 antikoerper, hth antikoerper, meis1b antikoerper, meis1 antikoerper

Hintergrund: Hox, Pbx, and Meis families of transcription factors form heteromeric complexes and bind DNA through specific homeobox domains. Hox proteins are involved in regulating tissue patterning during development, and they are also expressed n lineage- and stage-specific patterns during adult ematopoietic ifferentiation and in leukemias. The Hox proteins, which include paralog groups 1 to 10, have a low intrinsic binding affinity for DNA and are instead associated into cooperative DNA binding complexes with Pbx or the Pbx related Meis proteins, which result in an enhanced Hox-DNA binding affinity and an increased selectivity for the binding site. Both Meis1 and 2 (also known as Meis-related gene 1) are members of the TALE (three amino acid loop extension) family of homeodomain-containing proteins. In addition to binding with Hox proteins, Meis1 also forms heterodimers with the ubiquitously expressed Pbx proteins, including Pbx1, Pbx2 and Pbx3, and these complexes contain distinct DNA-binding specificities.Synonyms: Homeobox protein Meis1

Molekulargewicht: approx. 37 kDa

Gen-ID: 4211

NCBI Accession: NP_002389

UniProt: O00470

Pathways: Chromatin Binding