BNIP2 Antikörper

Produktnummer ABIN498505

Produktdetails anti-BNIP2 Antikörper

Target: BNIP2 (BCL2/adenovirus E1B 19kDa Interacting Protein 2 (BNIP2))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BNIP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody detects endogenous levels of BNIP-2 protein. (region surrounding Glu122)

Kreuzreaktivität (Details): Species reactivity (tested):Human, Mouse.

Aufreinigung: Affinity Chromatography using epitope-specific immunogen.

Anwendungsinformationen

Applikationshinweise: Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu BNIP2

Target: BNIP2 (BCL2/adenovirus E1B 19kDa Interacting Protein 2 (BNIP2))

Andere Bezeichnung: BNIP2 (BNIP2 Produkte)

Synonyme: BNIP-2 antikoerper, NIP2 antikoerper, 5730523P12Rik antikoerper, BNIP2beta antikoerper, Nip21 antikoerper, BCL2 interacting protein 2 antikoerper, BCL2/adenovirus E1B interacting protein 2 antikoerper, BNIP2 antikoerper, Bnip2 antikoerper

Hintergrund: The adenovirus E1B protein is a viral homolog of the Bcl-2 family of proteins that are involved in regulating cell death. A family of interacting proteins, which are designated Nip or Bnip and include BNIP-1, BNIP-2, BNIP-3 and Nix, associate with both the E1B protein and Bcl-2 proteins to mediate apoptotic signaling. BNIP-1 contains a hydrophobic transmembrane domain, which enables its localization to the nuclear envelope, endoplasmic recticulum and mitochondria. BNIP-2, (previously designated Nip2 and Nip21 in human and mouse respectively), shares homology with the non-catalytic domain of Cdc42 GTPase-activating protein (Cdc42GAP). Through binding to Cdc42GAP, BNIP-2 enhances the GTPase activity of Cdc42GAP, facilitating the hydrolysis of GTP bound to Cdc42 and thereby, mediating the signaling pathways involving receptor kinases, small GTPases and apoptotic proteins. Nix, which is also designated Nip3L or Bnip3L, is highly related to BNIP-3, and both proteins localize to the mitochondria where they associate with Bcl-2 proteins.Synonyms: BCL2/adenovirus E1B 19 kDa protein-interacting protein 2, NIP2

Molekulargewicht: approx. 34 kDa

Gen-ID: 663

NCBI Accession: NP_004321

UniProt: Q12982

Pathways: Regulation of Muscle Cell Differentiation