MAG Antikörper

Produktnummer ABIN4951814

Produktdetails anti-MAG Antikörper

Target: MAG (Myelin Associated Glycoprotein (MAG))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAG Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: Antigen affinity

Immunogen: Amino acids EPPELDLSYSHSDLGKRPTKDSYTLTEELAEYAEIRVK of human MAG/SIGLEC4A were used as the immunogen for the Myelin-associated glycoprotein antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Myelin-associated glycoprotein antibody should be determined by the researcher.\. Western blot: 0.1-0.5 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the Myelin-associated glycoprotein antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu MAG

Target: MAG (Myelin Associated Glycoprotein (MAG))

Andere Bezeichnung: MAG / Myelin-associated glycoprotein (MAG Produkte)

Synonyme: GMA antikoerper, S-MAG antikoerper, SIGLEC-4A antikoerper, SIGLEC4A antikoerper, siglec-4 antikoerper, MAG antikoerper, Gma antikoerper, siglec-4a antikoerper, myelin associated glycoprotein antikoerper, myelin-associated glycoprotein antikoerper, MAG antikoerper, mag antikoerper, Mag antikoerper

Hintergrund: MAG (Myelin-associated glycoprotein), also known as SIGLEC4A, is a cell membrane glycoprotein that is a member of the SIGLEC family of proteins and is a functional ligand of the NOGO-66 receptor, NgR. It is thought to be involved in the process of myelination. Cleavage of GPI-linked proteins from axons protects growth cones from MAG-induced collapse, and dominant-negative NgR eliminates MAG inhibition of neurite outgrowth. MAG-resistant embryonic neurons were rendered MAG-sensitive by expression of NgR. MAG binds specifically to an NgR-expressing cell line in a GPI-dependent and sialic acid-independent manner. Experiments blocking NgR from interacting with MAG prevented inhibition of neurite outgrowth by MAG. In cultured human embryonic kidney (HEK) cells expressing the NOGO receptor, p75(NTR) was required for MAG-induced intracellular calcium elevation.

UniProt: P20916

Pathways: Neurotrophin Signalübertragung