KEAP1 Antikörper (AA 25-205)

Produktnummer ABIN4951533

Produktdetails anti-KEAP1 Antikörper

Target: KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))

Bindungsspezifität: AA 25-205

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KEAP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: Antigen affinity

Immunogen: Amino acids 25-205 of human KEAP1 were used as the immunogen for the KEAP1 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the KEAP1 antibody should be determined by the researcher.\. Western blot: 0.1-0.5 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the KEAP1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu KEAP1

Target: KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))

Andere Bezeichnung: KEAP1 (KEAP1 Produkte)

Synonyme: INrf2 antikoerper, KLHL19 antikoerper, INRF2 antikoerper, mKIAA0132 antikoerper, Inrf2 antikoerper, fb36f11 antikoerper, keap1 antikoerper, wu:fb36f11 antikoerper, KEAP1 antikoerper, klhl19 antikoerper, zgc:171654 antikoerper, kelch like ECH associated protein 1 antikoerper, kelch-like ECH-associated protein 1 antikoerper, Kelch-like ECH-associated protein 1 antikoerper, kelch-like ECH-associated protein 1a antikoerper, kelch like ECH associated protein 1 L homeolog antikoerper, kelch-like ECH-associated protein 1b antikoerper, KEAP1 antikoerper, Keap1 antikoerper, keap1a antikoerper, keap1 antikoerper, keap1.L antikoerper, keap1b antikoerper

Hintergrund: KELCH-LIKE ECH-ASSOCIATED PROTEIN 1 is a protein that in humans is encoded by the KEAP1 gene. Keap1 contains a central BTB/POZ domain and a C-terminal double glycine repeat (DGR), or Kelch, module. Keap1 has been shown to interact with Nrf2, a master regulator of the antioxidant response, which is important for the amelioration of oxidative stress. In the presence of the electrophilic agent diethylmalate, Nrf2 activity is released from Keap1 and Nrf2 translocate to the nucleus. Under quiescent conditions, Nrf2 is anchored in the cytoplasm through binding to Keap1, which, in turn, facilitates the ubiquitination and subsequent proteolysis of Nrf2. Because Nrf2 activation leads to a coordinated antioxidant and anti-inflammatory response, and Keap1 represses Nrf2 activation, Keap1 has become a very attractive drug target.

UniProt: Q14145

Pathways: Maintenance of Protein Location