TSHR, B Chain Antikörper

Produktnummer ABIN4949912

Produktdetails anti-TSHR, B Chain Antikörper

Target: TSHR, B Chain (Thyroid Stimulating Hormone Receptor, B Chain (TSHR, B Chain))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TSHR, B Chain Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: Protein G affinity chromatography

Immunogen: Recombinant human TSHR beta chain protein was used as the immunogen for this TSH Receptor antibody.

Klon: SPM222

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the TSH Receptor antibody to be titered up or down for optimal performance.\. FACS: 0.5-1 μg/10^6 cells in 0.1ml,IF: 1-2 μg/mL,IHC (FFPE): 1-2 μg/mL for 30 min at RT

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the TSH Receptor antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Details zu TSHR, B Chain

Target: TSHR, B Chain (Thyroid Stimulating Hormone Receptor, B Chain (TSHR, B Chain))

Andere Bezeichnung: Thyroid Stimulating Hormone Receptor / TSHR (beta chain) (TSHR, B Chain Produkte)

Hintergrund: Thyroid-stimulating hormone (TSH, also known as thyrotropin) is a glycoprotein involved in the control of thyroid structure and metabolism, which stimulates the release of the thyroid hormones. TSH is regulated by thyroid hormone (T3) and various retinoid compounds. TSH binds to the thyroid-stimulating hormone receptor (TSHR), which is cleaved into two subunits, A and B, and plays a major role in regulating thyroid function. The third cytoplasmic loop of TSHR has been identified as critical for its role in regulating inositol phosphate and cAMP formation. In Graves disease, an autoimmune disorder, TSHR is activated by autoantibodies, which may be stimulated by the cleavage of the A and B subunits.