TDP2 Antikörper
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- Target Alle TDP2 Antikörper anzeigen
- TDP2 (tyrosyl-DNA phosphodiesterase 2 (TDP2))
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser TDP2 Antikörper ist unkonjugiert
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Applikation
- Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Aufreinigung
- Protein G affinity chromatography
- Immunogen
- Human recombinant full length protein was used as the immunogen for this TDP2 antibody.
- Klon
- TDP2-1258
- Isotyp
- IgG2b kappa
- Top Product
- Discover our top product TDP2 Primärantikörper
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- Applikationshinweise
- The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the TDP2 antibody to be titered up or down for optimal performance.\. FACS: 0.5-1 μg/10^6 cells in 0.1ml,IF: 0.5-1 μg/mL,IHC (FFPE): 0.5-1 μg/mL for 30 min at RT
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1 mg/mL
- Buffer
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
- Konservierungsmittel
- Azide free
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Store the TDP2 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
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- Target
- TDP2 (tyrosyl-DNA phosphodiesterase 2 (TDP2))
- Andere Bezeichnung
- TDP2 / ETS1 associated protein II (TDP2 Produkte)
- Synonyme
- AD022 antikoerper, EAP2 antikoerper, EAPII antikoerper, TTRAP antikoerper, dJ30M3.3 antikoerper, hTDP2 antikoerper, ad022 antikoerper, eap2 antikoerper, ttrap antikoerper, D13Ertd656e antikoerper, Ttrap antikoerper, tdp2 antikoerper, ttrapl antikoerper, tyrosyl-DNA phosphodiesterase 2 antikoerper, tyrosyl-DNA phosphodiesterase 2 S homeolog antikoerper, tyrosyl-DNA phosphodiesterase 2b antikoerper, TDP2 antikoerper, tdp2.S antikoerper, Tdp2 antikoerper, tdp2b antikoerper
- Hintergrund
- This mAb recognizes a protein of 41 kDa, which is identified as TDP2, or ETS1 associated protein II. It is a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors. DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation. Has also 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. May also act as a negative regulator of ETS1 and may inhibit nuclear factor-kappa-B activation.
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