ELAVL1 Antikörper
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- Target Alle ELAVL1 Antikörper anzeigen
- ELAVL1 (ELAV (Embryonic Lethal, Abnormal Vision, Drosophila)-Like 1 (Hu Antigen R) (ELAVL1))
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser ELAVL1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Kreuzreaktivität
- Human
- Aufreinigung
- Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
- Immunogen
- This ELAVL1 monoclonal antibody is generated from mouse immunized with ELAVL1 recombinant protein.
- Klon
- 4C3
- Isotyp
- IgG1
- Top Product
- Discover our top product ELAVL1 Primärantikörper
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- Applikationshinweise
- WB 1:300-5000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 0.5 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C for 12 months.
- Haltbarkeit
- 12 months
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- Target
- ELAVL1 (ELAV (Embryonic Lethal, Abnormal Vision, Drosophila)-Like 1 (Hu Antigen R) (ELAVL1))
- Andere Bezeichnung
- ELAVL1 (ELAVL1 Produkte)
- Synonyme
- ELAV1 antikoerper, HUR antikoerper, Hua antikoerper, MelG antikoerper, HuR antikoerper, 2410055N02Rik antikoerper, W91709 antikoerper, elra antikoerper, fa25f08 antikoerper, fb59a02 antikoerper, fc60g02 antikoerper, hua antikoerper, wu:fa25f08 antikoerper, wu:fb59a02 antikoerper, wu:fc60g02 antikoerper, zHuA antikoerper, Elavl1 antikoerper, Xel-1 antikoerper, elav1 antikoerper, elrA antikoerper, hur antikoerper, melg antikoerper, p36 antikoerper, ElrA antikoerper, elavl1 antikoerper, elavl1-a antikoerper, elavl1-b antikoerper, ELAV like RNA binding protein 1 antikoerper, ELAV-like protein 1 antikoerper, ELAV (embryonic lethal, abnormal vision)-like 1 (Hu antigen R) antikoerper, ELAV like RNA binding protein 1a antikoerper, ELAV like RNA binding protein 1 L homeolog antikoerper, ELAV like RNA binding protein 1 S homeolog antikoerper, ELAVL1 antikoerper, Elavl1 antikoerper, elav1 antikoerper, elavl1a antikoerper, elavl1.L antikoerper, elavl1.S antikoerper
- Hintergrund
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Synonyms: HUR, Hua, MelG, ELAV1, ELAV-like protein 1, Hu-antigen R, ELAVL1
Background: RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability (PubMed:14517288, PubMed:18285462). Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation (By similarity). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:8626503, PubMed:17632515, PubMed:18285462, PubMed:23519412). Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro (PubMed:8626503). With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (By similarity).
- Gen-ID
- 1994
- UniProt
- Q15717
- Pathways
- AMPK Signaling
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