TGFBR3 Antikörper

Produktnummer ABIN4905408

Produktdetails anti-TGFBR3 Antikörper

Target: TGFBR3 (Transforming Growth Factor, beta Receptor III (TGFBR3))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TGFBR3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktmerkmale: Transforming growth factor-β (TGF-β) superfamily members are critical regulators of cell proliferation and differentiation, developmental patterning and morphogenesis, and disease pathogenesis (1-4). TGF-β elicits signaling through three cell surface receptors: type I (RI), type II (RII), and type III (RIII). Type I and type II receptors are serine/threonine kinases that form a heteromeric complex. In response to ligand binding, the type II receptors form a stable complex with the type I receptors allowing phosphorylation and activation of type I receptor kinases (5). The type III receptor, also known as betaglycan, is a transmembrane proteoglycan with a large extracellular domain that binds TGF-β with high affinity but lacks a cytoplasmic signaling domain (6,7). Expression of the type III receptor can regulate TGF-β signaling through presentation of the ligand to the signaling complex. The only known direct TGF-β signaling effectors are the Smad family proteins, which transduce signals from the cell surface directly to the nucleus to regulate target gene transcription (8,9).

Aufreinigung: Affinity purification

Immunogen: Recombinant protein of human TGFBR3.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze/thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C.

Details zu TGFBR3

Target: TGFBR3 (Transforming Growth Factor, beta Receptor III (TGFBR3))

Andere Bezeichnung: TGFBR3 (TGFBR3 Produkte)

Synonyme: TGFBR3 antikoerper, DKFZp469I0915 antikoerper, BGCAN antikoerper, betaglycan antikoerper, 1110036H20Rik antikoerper, AU015626 antikoerper, AW215636 antikoerper, TBRIII antikoerper, transforming growth factor beta receptor 3 antikoerper, transforming growth factor, beta receptor III antikoerper, TGFBR3 antikoerper, tgfbr3 antikoerper, Tgfbr3 antikoerper

Gen-ID: 7049

UniProt: Q03167