MARCKS Antikörper

Produktnummer ABIN4904308

Produktdetails anti-MARCKS Antikörper

Target: MARCKS (Myristoylated Alanine-Rich Protein Kinase C Substrate (MARCKS))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MARCKS Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktmerkmale: The expression of a major cellular substrate for protein kinase C, the MARCKS protein, is regulated in a cell-, tissue-, and developmental stage-specific fashion, in addition, this expression can be stimulated acutely by various cytokines in certain cell types (1). MARCKS) binds calmodulin and is a predominant, specific substrate of PKC which is phosphorylated during macrophage and neutrophil activation, growth factor-dependent mitogenesis and neurosecretion, it is redistributed from plasma membrane to cytoplasm when phosphorylated and is involved in leukocyte motility. It has been reported that MARCKS is a filamentous (F) actin crosslinking protein, with activity that is inhibited by PKC-mediated phosphorylation and by binding to calcium-calmodulin. MARCKS may be a regulated crossbridge between actin and the plasma membrane, and modulation of the actin crosslinking activity of the MARCKS protein by calmodulin and phosphorylation represents a potential convergence of the calcium-calmodulin and PKC signal transduction pathways in the regulation of the actin cytoskeleton (2).

Aufreinigung: Affinity purification

Immunogen: A synthetic peptide of human MARCKS.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze/thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C.

Details zu MARCKS

Target: MARCKS (Myristoylated Alanine-Rich Protein Kinase C Substrate (MARCKS))

Andere Bezeichnung: MARCKS (MARCKS Produkte)

Synonyme: 80K-L antikoerper, MACS antikoerper, PKCSL antikoerper, PRKCSL antikoerper, KINC antikoerper, Macs antikoerper, marcks antikoerper, MGC89127 antikoerper, MARCKS antikoerper, macs antikoerper, wu:fb55c06 antikoerper, wu:fb92d04 antikoerper, wu:fc19b04 antikoerper, wu:fc44a10 antikoerper, zgc:110235 antikoerper, fc34g03 antikoerper, fc38c06 antikoerper, wu:fc34g03 antikoerper, wu:fc38c06 antikoerper, zgc:109978 antikoerper, myristoylated alanine rich protein kinase C substrate antikoerper, myristoylated alanine-rich protein kinase C substrate antikoerper, methyl binding domain106 antikoerper, myristoylated alanine-rich protein kinase C substrate b antikoerper, myristoylated alanine-rich protein kinase C substrate S homeolog antikoerper, myristoylated alanine-rich protein kinase C substrate a antikoerper, MARCKS antikoerper, Marcks antikoerper, marcks antikoerper, mbd106 antikoerper, marcksb antikoerper, marcks.S antikoerper, marcksa antikoerper

Gen-ID: 4082

UniProt: P29966