EEA1 Antikörper
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- Target Alle EEA1 Antikörper anzeigen
- EEA1 (Early Endosome Antigen 1 (EEA1))
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser EEA1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Produktmerkmale
- EEA1 is an early endosomal marker and a Rab5 effector protein essential for early endosomal membrane fusion and trafficking (1-2). The carboxy terminus of EEA1 contains a FYVE domain which binds to phosphatidylinositol-3-phosphate (PtdIns(3)P), targeting EEA1 to early endosomes (3). The stable association of EEA1 with the endosomal membrane is regulated by PI3 kinase, Rab5 and calcium/calmodulin (4-6). Once on the membrane, EEA1 interacts with Rab5, NSF and syntaxin 13 to promote early endosomal membrane docking and fusion (7).1.Mu, F.T. et al. (1995) J. Biol. Chem. 270, 13503-13511.2.Christoforidis, S. et al. (1999) Nature 397, 621-625.3.Gaullier, J.M. et al. (1998) Nature 394, 432-433.4.Patki, V. et al. (1997) Proc. Natl. Acad. Sci. USA 94, 7326-7330.5.Lawe, D.C. et al. (2003) Mol. Biol. Cell 14, 2935-2945.6.Simonsen, A. et al. (1998) Nature 394, 494-498.7.McBride, H.M. et al. (1999) Cell 98, 377-386.
- Aufreinigung
- Affinity purification
- Immunogen
- Recombinant Protein of human EEA1.
- Isotyp
- IgG
- Top Product
- Discover our top product EEA1 Primärantikörper
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- Applikationshinweise
- WB 1:500-1:2000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.4
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze/thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C.
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- Target
- EEA1 (Early Endosome Antigen 1 (EEA1))
- Andere Bezeichnung
- EEA1 (EEA1 Produkte)
- Synonyme
- MST105 antikoerper, MSTP105 antikoerper, ZFYVE2 antikoerper, im:7151048 antikoerper, si:ch211-276p10.2 antikoerper, A430109M19Rik antikoerper, B230358H09Rik antikoerper, early endosome antigen 1 antikoerper, early endosome antigen 1 S homeolog antikoerper, EEA1 antikoerper, eea1 antikoerper, Eea1 antikoerper, eea1.S antikoerper
- Gen-ID
- 8411
- UniProt
- Q15075
- Pathways
- Toll-Like Receptors Cascades
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