BRD3 Antikörper

Produktnummer ABIN4903072

Produktdetails anti-BRD3 Antikörper

Target: BRD3 (Bromodomain Containing 3 (BRD3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BRD3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktmerkmale: Nuclear protein in testis (NUT) is normally confined to the germ cells of the testis and ovary (1,2). NUT midline carcinoma (NMC) is a recently recognized cancer that is defined by the presence of chromosomal rearrangements involving the NUT gene on chromosome 15q14 (3). In most cases the chromosomal translocation occurs between NUT and BRD4 on chromosome 19, resulting in the formation of a BRD4-NUT fusion protein. In the remaining tumors, variant NUT rearrangements are present involving BRD3, a very close homolog of BRD4. BRD4-NUT and BRD3-NUT encode fusion proteins that appear to contribute to carcinogenesis by blocking epithelial cell differentiation. NMCs, which are aggressive and highly lethal carcinomas, are morphologically indistinguishable from other poorly differentiated carcinomas. Given the limited expression of endogenous NUT protein, this antibody can be used to detect NUT fusion proteins in tissues by immunohistochemistry and immunofluorescence (2).

Aufreinigung: Affinity purification

Immunogen: Recombinant protein of human BRD3.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze/thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C.

Details zu BRD3

Target: BRD3 (Bromodomain Containing 3 (BRD3))

Andere Bezeichnung: BRD3 (BRD3 Produkte)

Synonyme: ORFX antikoerper, RING3L antikoerper, 2410084F24Rik antikoerper, AW060456 antikoerper, Fsrg2 antikoerper, RINGL3 antikoerper, brd3 antikoerper, fi36b10 antikoerper, wu:fa13h06 antikoerper, wu:fc01d09 antikoerper, wu:fc74a08 antikoerper, wu:fi04h10 antikoerper, wu:fi36b10 antikoerper, BRD3 antikoerper, ring3l antikoerper, fa28f05 antikoerper, wu:fa28f05 antikoerper, wu:fc56a11 antikoerper, wu:fj66d12 antikoerper, zgc:77289 antikoerper, bromodomain containing 3 antikoerper, bromodomain containing 3a antikoerper, bromodomain containing 3 S homeolog antikoerper, bromodomain-containing protein 3 antikoerper, bromodomain containing 3b antikoerper, BRD3 antikoerper, Brd3 antikoerper, brd3a antikoerper, brd3.S antikoerper, LOC100410652 antikoerper, LOC100354641 antikoerper, brd3b antikoerper

Gen-ID: 8019

UniProt: Q15059

Pathways: Chromatin Binding