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PRMT5 Antikörper (Internal Region)

PRMT5 Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Schwein WB, EIA Wirt: Ziege Polyclonal unconjugated
Produktnummer ABIN401522
  • Target Alle PRMT5 Antikörper anzeigen
    PRMT5 (Protein Arginine Methyltransferase 5 (PRMT5))
    Bindungsspezifität
    • 15
    • 10
    • 9
    • 8
    • 8
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reaktivität
    • 88
    • 36
    • 18
    • 7
    • 6
    • 6
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    Human, Maus, Ratte, Hund, Rind (Kuh), Schwein
    Wirt
    • 79
    • 6
    • 2
    • 1
    Ziege
    Klonalität
    • 71
    • 16
    • 1
    Polyklonal
    Konjugat
    • 47
    • 6
    • 6
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser PRMT5 Antikörper ist unkonjugiert
    Applikation
    • 64
    • 39
    • 37
    • 14
    • 13
    • 13
    • 12
    • 8
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Sequenz
    RACREKDRDP EAQ
    Spezifität
    This antibody detects PRMT5 (Internal). It is expected to recognize both isoforms (NP_006100.2, NP_001034708.1).
    Kreuzreaktivität (Details)
    Species reactivity (expected):Mouse, Rat, Pig, Dog, CowSpecies reactivity (tested):Human
    Aufreinigung
    Ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
    Immunogen
    Peptide from the internal region of the protein sequence according to NP_006100.2, NP_001034708.1. Genename: PRMT5
    Top Product
    Discover our top product PRMT5 Primärantikörper
  • Applikationshinweise
    Peptide ELISA: antibody detection limit dilution 1: 16000. Western blot: 1-3 μg/mL. Approx 70 kDa band observed in Jurkat lysates (calculated MW of72.0 kDa and 71.0 kDa according to NP_006100.2, NP_001034708.1).
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    0.5 mg/mL
    Buffer
    Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C.
  • Target
    PRMT5 (Protein Arginine Methyltransferase 5 (PRMT5))
    Andere Bezeichnung
    PRMT5 (PRMT5 Produkte)
    Synonyme
    HRMT1L5 antikoerper, IBP72 antikoerper, JBP1 antikoerper, SKB1 antikoerper, SKB1Hs antikoerper, Jbp1 antikoerper, Skb1 antikoerper, si:zc14a17.2 antikoerper, skb1 antikoerper, wu:fb95f10 antikoerper, zgc:110669 antikoerper, hsl7 antikoerper, DDBDRAFT_0187422 antikoerper, DDBDRAFT_0235403 antikoerper, DDB_0187422 antikoerper, DDB_0235403 antikoerper, NV18830 antikoerper, jbp1 antikoerper, ibp72 antikoerper, skb1hs antikoerper, hrmt1l5 antikoerper, protein arginine methyltransferase 5 antikoerper, protein arginine N-methyltransferase 5 antikoerper, protein arginine methyltransferase 5 L homeolog antikoerper, putative arginine N-methyltransferase, type II antikoerper, Skb1 family protein antikoerper, Protein arginine N-methyltransferase 5 antikoerper, PRMT5 antikoerper, Prmt5 antikoerper, prmt5 antikoerper, prmt5.L antikoerper, LOC100115766 antikoerper, prmt-5 antikoerper
    Hintergrund
    Arginine methylation is an irreversible post translational modification linked to protein activity. At least three types of PRMT enzymes have been identified in mammalian cells. These enzymes have been shown to have essential regulatory functions by methylation of key proteins in several fundamental areas. These proteins include nuclear proteins (Histone 2A, 3, 4), IL enhancer binding factor, nuclear factors (NF45, 90, ILF3, Nucleolin, STAT1, Poly(A) binding protein II), cell cycle proteins (phosphoprotein phosphatase 2A), signal transduction proteins (FGF2, Fibrillarin, FN, INFAR1, Jak, MBP, Src-adaptor Sam68), apoptosis proteins (FADD, ICE-like protease), and viral proteins (Hepatitis C NS3 RNA Helicase, HIV TAR). The mammalian PRMT family currently consists of 5 members that share two large domains of homology. Outside of these domains, epitopes were identified and antibodies against all five PRMT members have been developed. These antibodies can be utilized to explore arginine methylation and its regulatory functions.Synonyms: 72 kDa ICln-binding protein, HRMT1L5, Histone-arginine N-methyltransferase PRMT5, IBP72, JBP1, Jak-binding protein 1, Protein Arginine N-Methyltransferase 5, SKB1, SKB1Hs
    Gen-ID
    10419
    NCBI Accession
    NP_001034708
    UniProt
    O14744
    Pathways
    Chromatin Binding, Regulation of Muscle Cell Differentiation, Ribonucleoprotein Complex Subunit Organization, Skeletal Muscle Fiber Development
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