STUB1 Antikörper (C-Term)
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- Target Alle STUB1 Antikörper anzeigen
- STUB1 (STIP1 Homology and U-Box Containing Protein 1 (STUB1))
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Bindungsspezifität
- AA 203-231, C-Term
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser STUB1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Homologie
- C, M
- Aufreinigung
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
- Immunogen
- This STUB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 203-231 amino acids from the C-terminal region of human STUB1.
- Klon
- RB7393
- Isotyp
- Ig Fraction
- Top Product
- Discover our top product STUB1 Primärantikörper
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- Applikationshinweise
- WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100. IHC-P: 1:50~100
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
- Haltbarkeit
- 6 months
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- Target
- STUB1 (STIP1 Homology and U-Box Containing Protein 1 (STUB1))
- Andere Bezeichnung
- CHIP (STUB1) (STUB1 Produkte)
- Synonyme
- CHIP antikoerper, HSPABP2 antikoerper, NY-CO-7 antikoerper, SDCCAG7 antikoerper, UBOX1 antikoerper, 0610033N24Rik antikoerper, 2210017D18Rik antikoerper, 2310040B03Rik antikoerper, AW046544 antikoerper, Chip antikoerper, wu:fc22f04 antikoerper, zgc:56076 antikoerper, STUB1 antikoerper, chip antikoerper, ATCHIP antikoerper, CARBOXYL TERMINUS OF HSC70-INTERACTING PROTEIN antikoerper, carboxyl terminus of HSC70-interacting protein antikoerper, STIP1 homology and U-box containing protein 1 antikoerper, STIP1 homology and U-Box containing protein 1 antikoerper, STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase L homeolog antikoerper, STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase antikoerper, STIP1 homology and U box-containing protein 1 antikoerper, carboxyl terminus of HSC70-interacting protein antikoerper, STUB1 antikoerper, Stub1 antikoerper, stub1 antikoerper, stub1.L antikoerper, LOC100282870 antikoerper, CHIP antikoerper
- Hintergrund
- CHIP is an E3 ligase for nNOS whose action is facilitated by (and possibly requires) its interaction with nNOS-bound hsp70. Co-chaperone CHIP, possibly with another E3 ligase(s), modulates the ubiquitylation of mutant Cu/Zn-superoxide dismutase and renders them more susceptible for proteasomal degradation. CHIP functions as a negative regulator of AR transcriptional activity by promoting AR degradation. CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survival. CHIP can interact with the Smad1/Smad4 proteins and block BMP signal transduction through the ubiquitin-mediated degradation of Smad proteins. CHIP E3 controls both the association of Hsp70/Hsp90 chaperones with ErbB2 and the down-regulation of ErbB2 induced by inhibitors of Hsp90. CHIP is associated with Parkin and enhances its ubiquitin ligase activity related to Parkinson's disease.
- Molekulargewicht
- 34856
- Gen-ID
- 10273
- NCBI Accession
- NP_005852
- UniProt
- Q9UNE7
- Pathways
- Regulation of Hormone Metabolic Process, Response to Water Deprivation
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