MLLT6 Antikörper (C-Term)

Produktnummer ABIN390132

Produktdetails anti-MLLT6 Antikörper

Target: MLLT6 (Myeloid/lymphoid Or Mixed-lineage Leukemia, Translocated To, 6 (MLLT6))

Bindungsspezifität: AA 1056-1086, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MLLT6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This MLLT6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1056-1086 amino acids from the C-terminal region of human MLLT6.

Klon: RB2251-2252

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Details zu MLLT6

Target: MLLT6 (Myeloid/lymphoid Or Mixed-lineage Leukemia, Translocated To, 6 (MLLT6))

Andere Bezeichnung: MLLT6 (MLLT6 Produkte)

Synonyme: AF17 antikoerper, MLLT6, PHD finger containing antikoerper, MLLT6 antikoerper

Hintergrund: Band 11q23 chromosome locations are associated with approximately 10 % of patients with acute lymphoblastic leukemia (ALL) and more than 5 % of patients with acute myeloid leukemia (AML). 11q23 translocation associated leukemias typically jointly express lymphoid and myeloid markers and exhibit poor prognosis. The gene at 11q23 involved in the translocations is known by multiple names, including ALL1, HRX, MLL, and TRX1. One of the more infrequent translocations, t(11,17)(q23,q21), MLLT6, encodes a protein of 1,093 amino acids, containing a leucine-zipper dimerization motif 3-prime to the fusion point and a cysteine-rich domain at the end terminus that can be arranged in 3 zinc fingers. MMLT6 contains amino acid runs associated with domains involved in transcriptional repression or activation. It has been proposed that MLLT6 represses truncated ALL1 function or inhibits function of the normal protein in leukemic cells.

Molekulargewicht: 112048

Gen-ID: 4302

NCBI Accession: NP_005928

UniProt: P55198