KCNQ1 Antikörper (C-Term)

Produktnummer ABIN375129

Produktdetails anti-KCNQ1 Antikörper

Target: KCNQ1 (Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 1 (KCNQ1))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh)

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser KCNQ1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: C-EQLTVPRRGP DEGS

Spezifität: This antibody is expected to recognize both reported isoforms of KCNQ1.

Kreuzreaktivität (Details): Species reactivity (expected):Bovine, Canine, Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography.

Immunogen: Peptide with sequence from the C-Terminus of the protein sequence

Anwendungsinformationen

Applikationshinweise: Peptide ELISA: 1/16000. Western Blot: Use at 1-3 μg/mL. Approx.60 kDa band observed in Human Heart lysates (calculated MW of 61.0 kDaaccording to NP_861463.1). An additional band of unknown identity was also consistently observed at 20 kDa. Thisband was successfully blocked by incubation with the immunizing peptide.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris-saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu KCNQ1

Target: KCNQ1 (Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 1 (KCNQ1))

Andere Bezeichnung: KCNQ1 (KCNQ1 Produkte)

Synonyme: ATFB1 antikoerper, ATFB3 antikoerper, JLNS1 antikoerper, KCNA8 antikoerper, KCNA9 antikoerper, KVLQT1 antikoerper, Kv1.9 antikoerper, Kv7.1 antikoerper, LQT antikoerper, LQT1 antikoerper, RWS antikoerper, SQT2 antikoerper, WRS antikoerper, CG12215 antikoerper, CG12915 antikoerper, CG33135 antikoerper, DKCNQ antikoerper, Dmel\\CG33135 antikoerper, dKCNQ antikoerper, kcnq1 antikoerper, KCNQ1 antikoerper, kqt-3 antikoerper, kv7.1 antikoerper, Kvlqt1 antikoerper, KvLQT-1 antikoerper, kcnq1-A antikoerper, xkvlqt1 antikoerper, zgc:158384 antikoerper, AW559127 antikoerper, Kcna9 antikoerper, KvLQT1 antikoerper, potassium voltage-gated channel subfamily Q member 1 antikoerper, KCNQ potassium channel antikoerper, potassium voltage-gated channel, KQT-like subfamily, member 1 antikoerper, potassium channel, voltage gated KQT-like subfamily Q, member 1 antikoerper, voltage gated potassium channel subunit antikoerper, potassium channel, voltage gated KQT-like subfamily Q, member 1 L homeolog antikoerper, potassium voltage-gated channel, subfamily Q, member 1 antikoerper, KCNQ1 antikoerper, KCNQ antikoerper, kcnq1 antikoerper, Kcnq1 antikoerper, kcnq1.L antikoerper

Hintergrund: This gene encodes a protein for a voltage-gated potassium channel required for the repolarization phase of the cardiac action potential. The gene product can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome, Romano-Ward syndrome, Jervell and Lange-Nielsen syndrome and familial atrial fibrillation. The gene is located in a region of chromosome 11 that contains a large number of contiguous genes that are abnormally imprinted in cancer and the Beckwith-Wiedemann syndrome. Two alternative transcripts encoding distinct isoforms have been described (from EntrezGene).Synonyms: IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1, KCNA8, KCNA9, KQT-like 1, KVLQT1, Potassium voltage-gated channel subfamily KQT member 1, Voltage-gated potassium channel subunit Kv7.1

Gen-ID: 3784

NCBI Accession: NP_000209

UniProt: P51787

Pathways: Negative Regulation of Hormone Secretion, Sensory Perception of Sound