ESRRG Antikörper (Internal Region)
-
- Target Alle ESRRG Antikörper anzeigen
- ESRRG (Estrogen-Related Receptor gamma (ESRRG))
-
Bindungsspezifität
- Internal Region
-
Reaktivität
- Human, Maus, Hund
-
Wirt
- Ziege
-
Klonalität
- Polyklonal
-
Konjugat
- Dieser ESRRG Antikörper ist unkonjugiert
-
Applikation
- Western Blotting (WB)
- Spezifität
- This antibody reacts to ESRRG. This antibody is expected to recognise isoform 1.
- Kreuzreaktivität (Details)
-
Species reactivity (expected):Mouse, Canine.
Species reactivity (tested):Human. - Aufreinigung
- Affinity chromatography
- Immunogen
- Peptide with sequence CRMSNKDRHIDS, from the internal region of the protein sequence
- Top Product
- Discover our top product ESRRG Primärantikörper
-
-
- Applikationshinweise
-
Peptide ELISA: 1/16000. Western Blot: 0.2 - 0.6 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Konzentration
- 0,5 mg/mL
- Buffer
- Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freezing and thawing.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
-
- Target
- ESRRG (Estrogen-Related Receptor gamma (ESRRG))
- Andere Bezeichnung
- Estrogen-Related Receptor gamma (ESRRG Produkte)
- Synonyme
- ERR3 antikoerper, ERRgamma antikoerper, NR3B3 antikoerper, ESRRG antikoerper, USH2A antikoerper, DKFZp459J0417 antikoerper, err3 antikoerper, nr3b3 antikoerper, LOC100219115 antikoerper, errg antikoerper, errgamma antikoerper, esrrg antikoerper, errb/g antikoerper, esrrgl antikoerper, errbeta/gamma antikoerper, Errg antikoerper, mKIAA0832 antikoerper, estrogen related receptor gamma antikoerper, estrogen-related receptor gamma antikoerper, estrogen-related receptor gamma a antikoerper, estrogen-related receptor gamma b antikoerper, ESRRG antikoerper, esrrg antikoerper, Esrrg antikoerper, esrrga antikoerper, esrrgb antikoerper
- Hintergrund
- Estrogen related receptor (ERR gamma), a NR3 Steroid Receptor is an orphan member of the nuclear hormone receptor superfamily. All the ERR family members (1,2, and 3) share an almost identical DNA binding domain, which has 68 % amino acid identity with that of estrogen receptor. Studies involving the crystal structure of the LBD have shown a complex between ERR3 and SRC1. ERR gamma has been suggested to affect differentiation of the brain, heart, and kidney. ERR gamma binds as a monomer to an extended half site of the ERRE type (TCAAGGTCA). ERR gamma has been shown to interact with PGC1 alpha and has been implicated in the regulation of mitochondrial energy metabolism. In humans, ERR gamma pre mRNA undergoes extensive alternative splicing at the 5 prime end, yielding at least six mRNA splice variants and two protein isoforms that differ by 23 amino acids in the N terminus. ERR gamma has been shown to be overexpressed in breast tumors, and its expression is correlated with levels of ErbB4, a likely indicator of preferred clinical course. As a result, ERR gamma has been suggested to be a potential biomarker for favorable clinical course and, possibly, hormonal sensitivity, and as a candidate target for therapeutic development.Synonyms: ERR gamma-2, ERR3, ERRG2, ESRRG, Estrogen receptor-related protein 3, KIAA0832, NR3B3, Nuclear receptor subfamily 3 group B member 3
- Gen-ID
- 2104, 9606
- UniProt
- P62508
- Pathways
- Nuclear Receptor Transcription Pathway, Retinoic Acid Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway
-