MC2R Antikörper (N-Term)

Produktnummer ABIN374914

Produktdetails anti-MC2R Antikörper

Target: MC2R (Melanocortin 2 Receptor (Adrenocorticotropic Hormone) (MC2R))

Bindungsspezifität: N-Term

Reaktivität: Human

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser MC2R Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: This antibody reacts to MC2R / ACTHR.

Aufreinigung: Affinity chromatography

Immunogen: Peptide with sequence ENINNTARNNSDC, from the N Terminus of the protein sequence

Anwendungsinformationen

Applikationshinweise: Peptide ELISA: 1/32000. Western Blot: 1 - 3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0,5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu MC2R

Target: MC2R (Melanocortin 2 Receptor (Adrenocorticotropic Hormone) (MC2R))

Andere Bezeichnung: MC2-R (MC2R Produkte)

Synonyme: ACTHR antikoerper, ACTH-R antikoerper, MC2-R antikoerper, MC2R antikoerper, MC2 antikoerper, melanocortin 2 receptor antikoerper, MC2R antikoerper, Mc2r antikoerper, mc2r antikoerper

Hintergrund: MC2 receptor is the second member of the five known melanocortin receptors (MCRs) belonging to the rhodopsin-like family of G protein-coupled receptors (GPCRs). These five MCRs form a unique family of GPCRs, marked by their unusually short coding sequence and the absence of highly conserved amino acid residues or motifs common to most GPCRs. All MCRs signal through the cyclic adenosine 3', 5'-monophosphate (cAMP) pathway. MC2 receptor is the smallest MCR and the smallest known GPCR (297 amino acids). It exclusively binds the adrenocorticotrophic hormone (ACTH) and this binding plays a pivotal role in homeostasis, metabolism, and stress response. In contrast, the other four MCRs are activated by both ACTH and melanocyte-stimulating hormones (MSHs and mainly alpha-MSH). The MC2 receptor is predominantly expressed in the adrenal gland but is also found in the murine adipocyte. Mutations in MC2R can result in familial glucocorticoid deficiency.Synonyms: ACTH receptor, ACTH-R, ACTHR, Adrenocorticotropic hormone receptor, Adrenocorticotropin receptor, MC2R

Gen-ID: 4158, 9606

UniProt: Q01718

Pathways: cAMP Metabolic Process