PICK1 Antikörper (Internal Region)

Produktnummer ABIN374730

Produktdetails anti-PICK1 Antikörper

Target: PICK1 (Protein Interacting With Protein Kinase C, alpha 1 (PICK1))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte, Hund, Schwein

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser PICK1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Spezifität: This antibody reacts to PICK1.

Kreuzreaktivität (Details): Species reactivity (expected):Human, Canine, Pig.
Species reactivity (tested):Mouse, Rat.

Aufreinigung: Affinity chromatography

Immunogen: Peptide with sequence C-HYNKLQADPKQ, from the internal region of the protein sequence .Remarks: Reported variants represent identical protein (NP_036539.1, NP_001034672.1, NP_001034673.1).

Anwendungsinformationen

Applikationshinweise: Peptide ELISA: 1/16000. Western Blot: 1 - 3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu PICK1

Target: PICK1 (Protein Interacting With Protein Kinase C, alpha 1 (PICK1))

Andere Bezeichnung: PICK1 (PICK1 Produkte)

Synonyme: PICK antikoerper, PRKCABP antikoerper, Prkcabp antikoerper, prkcabp antikoerper, MGC131295 antikoerper, PICK1 antikoerper, DKFZp470L2127 antikoerper, protein interacting with PRKCA 1 antikoerper, protein interacting with C kinase 1 antikoerper, protein interacting with PRKCA 1 L homeolog antikoerper, PICK1 antikoerper, Pick1 antikoerper, pick1 antikoerper, pick1.L antikoerper

Hintergrund: PSD-95/DLG/ZO-1 (PDZ) domain containing proteins play a central role in synaptic membrane protein localization. The protein interacting with protein kinase C (PICK 1) is a synaptic PDZ domain protein that also contains a coiled-coil and acidic domain. Studies indicate that PICK 1 functions as a targeting and transport protein and has been shown to interact with protein kinase C alpha (PKC alpha), AMPA type glutamate receptors, and several other membrane receptors via its PDZ domain. The interaction of PICK 1 with PKC alpha is highly dependent on the activation of the kinase. It appears that PICK 1 directs the activated form of PKC alpha to membrane anchored GluR2. Once phosphorylated by PKC alpha, GluR2 is released from the synaptic anchor proteins. Once released, GluR2 is transported from the synaptic membrane in a PICK 1 dependent manner.Synonyms: PRKCA-binding protein, PRKCABP, Protein interacting with C kinase 1, Protein kinase C-alpha-binding protein

Gen-ID: 9463

NCBI Accession: NP_001034672

UniProt: Q9NRD5