IPO7 Antikörper (C-Term)

Produktnummer ABIN374249

Produktdetails anti-IPO7 Antikörper

Target: IPO7 (Importin 7 (IPO7))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Rind (Kuh), Ratte, Hund

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser IPO7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Sequenz: C-SSFNFGGPAP GMN

Spezifität: This antibody detects RanBP7/Importin-7 at C-term.

Kreuzreaktivität (Details): Species reactivity (expected):Mouse, Rat, Dog, CowSpecies reactivity (tested):Human.

Aufreinigung: Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide

Immunogen: Synthetic peptide from C-terminus of Human IPO7 (NP_006382.1). Genename: IPO7

Anwendungsinformationen

Applikationshinweise: Peptide ELISA: Limit dilution: 1/32000. Western blot: 0.1-1 μg/mL. Approx 120 kDa band observed in Human Brain lysates(predicted MW of 110 kDa according to NP_006382.1). Please note that an approx 30 kDaband of unknown identity is also consistently observed. Immunohistochemistry on Paraffin Sections: 5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, pH 7.3 containing of 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu IPO7

Target: IPO7 (Importin 7 (IPO7))

Andere Bezeichnung: RanBP7 / Importin-7 (IPO7 Produkte)

Synonyme: fb33d09 antikoerper, wu:fb33d09 antikoerper, zgc:66425 antikoerper, zgc:76878 antikoerper, imp7 antikoerper, ranbp7 antikoerper, Imp7 antikoerper, RANBP7 antikoerper, A330055O14Rik antikoerper, C330016G14 antikoerper, Ranbp7 antikoerper, importin 7 antikoerper, importin 7 S homeolog antikoerper, importin-7 antikoerper, karyopherin antikoerper, ipo7 antikoerper, ipo7.S antikoerper, IPO7 antikoerper, CpipJ_CPIJ002096 antikoerper, PTRG_08544 antikoerper, SJAG_03693 antikoerper, NAEGRDRAFT_71372 antikoerper, VDBG_01971 antikoerper, MGYG_08162 antikoerper, Tsp_01943 antikoerper, Tsp_01946 antikoerper, Ipo7 antikoerper

Hintergrund: The Importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran binding site of importin beta. Similar to importin beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta like transport receptors, namely importin beta itself, transportin, RanBP5 and Importin 7, directly bind and import ribosomal proteins.Synonyms: IMP7, IPO7, Ran-binding protein 7

Gen-ID: 10527

NCBI Accession: NP_006382

UniProt: O95373

Pathways: Protein targeting to Nucleus