GABRB2 Antikörper (Cytoplasmic Loop)
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- Target Alle GABRB2 Antikörper anzeigen
- GABRB2 (gamma-aminobutyric Acid (GABA) A Receptor, beta 2 (GABRB2))
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Bindungsspezifität
- Cytoplasmic Loop
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Reaktivität
- Human, Ratte, Maus, Hund, Non-Human Primate
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser GABRB2 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Spezifität
- Specific for the ~55k Beta-2 subunit of the GABAA Receptor in Western blots.
- Kreuzreaktivität (Details)
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Species reactivity (expected):Human, Canine, Chicken, Mouse and non-Human Primates.
Species reactivity (tested):Rat. - Aufreinigung
- Affinity Chromatography.
- Immunogen
- Fusion protein from the cytoplasmic loop of the Beta-2 subunit of Rat GABAA Receptor.
- Isotyp
- IgG
- Top Product
- Discover our top product GABRB2 Primärantikörper
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- Applikationshinweise
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Western Blot: 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.
- Handhabung
- Avoid repeated freezing and thawing.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store the antibody undiluted (in aliquots) at-20 °C.
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- Target
- GABRB2 (gamma-aminobutyric Acid (GABA) A Receptor, beta 2 (GABRB2))
- Andere Bezeichnung
- GABRB2 (GABRB2 Produkte)
- Synonyme
- GABRB2 antikoerper, GARB2 antikoerper, fj59e04 antikoerper, gabaabeta2 antikoerper, wu:fj59e04 antikoerper, zgc:136311 antikoerper, GABARB antikoerper, AI834970 antikoerper, C030002O17Rik antikoerper, C030021G16Rik antikoerper, Gabrab2 antikoerper, Gabrb-2 antikoerper, gamma-aminobutyric acid type A receptor beta2 subunit antikoerper, gamma-aminobutyric acid (GABA) A receptor, beta 2 antikoerper, gamma-aminobutyric acid type A receptor beta 2 subunit antikoerper, gamma-aminobutyric acid (GABA) A receptor, subunit beta 2 antikoerper, GABRB2 antikoerper, gabrb2 antikoerper, Gabrb2 antikoerper
- Hintergrund
- Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and sub-stance abuse. The GABAA-R is a multimeric subunit complex. To date six Alpha's, four Beta's and four Gamma's, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990, Whiting et al., 1999, Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for Alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a Gamma-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different Alpha-subunits of the receptor (McKernan et al., 2000, Mehta and Ticku, 1998, Ogris et al., 2004, Pöltl et al., 2003).Synonyms: GABA A receptor subunit beta-2, GABRB-2, Gamma-aminobutyric acid receptor subunit beta-2
- Gen-ID
- 25451
- NCBI Accession
- NP_037089
- UniProt
- P63138
- Pathways
- Sensory Perception of Sound, Synaptic Membrane
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