SKIL Antikörper (AA 600-684)

Produktnummer ABIN372440

Produktdetails anti-SKIL Antikörper

Target: SKIL (SKI-Like Oncogene (SKIL))

Bindungsspezifität: AA 600-684

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SKIL Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody recognizes SnoN.

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: Protein G Chromatography.

Immunogen: Synthetic peptide corresponding to a portion of the amino acids 600-684 of human SnoN.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry on Paraffin Sections: 5 μg/mL. Western blot: 1-3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: PBS containing 0.2 % Gelatin as stabilizer and 0.05 % Sodium Azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Details zu SKIL

Target: SKIL (SKI-Like Oncogene (SKIL))

Andere Bezeichnung: SKIL / SnoN (SKIL Produkte)

Synonyme: SNO antikoerper, SnoA antikoerper, SnoI antikoerper, SnoN antikoerper, Skir antikoerper, Sno antikoerper, SKIL antikoerper, DKFZp459L122 antikoerper, sno antikoerper, zgc:193698 antikoerper, SKI like proto-oncogene antikoerper, SKI-like proto-oncogene antikoerper, ski-like protein antikoerper, SKI-like antikoerper, SKI-like proto-oncogene b antikoerper, SKIL antikoerper, Skil antikoerper, LOC100010058 antikoerper, skil antikoerper, skilb antikoerper

Hintergrund: SnoN, an 80 KDa protein, is a member of ski family of nuclear proto-oncogenes involved in regulation of cellular transformation and differentiation. Primarily expressed in two isoforms, SnoN is localized in cytoplasm in normal tissues and non-tumorigenic primary epithelial cells. In cancer tissues or cells, SnoN is exclusively localized in the nucleus. It plays a vital role in inhibition of cell cycle arrest induced by TGF-. Upon morphological differentiation or cell-cycle arrest, SnoN translocates into the nucleus, binds to Smad2, Smad3, and Smad4 on TGF- -responsive promoters and represses their ability to activate expression of TGF- target genes. It has also been found to mediate transcriptional repression of thyroid hormone receptor, Mad and pRb. Increased expression of SnoN has been detected in many human tumor cell lines suggesting a clinical significance.Synonyms: SNO, Ski-like protein, Ski-related novel protein N, Ski-related oncogene, Ski-related protein, SnoA, Snol

Molekulargewicht: 77 kDa.

Gen-ID: 6498

NCBI Accession: NP_001138569

UniProt: P12757

Pathways: Positive Regulation of Response to DNA Damage Stimulus