GRIN1/NMDAR1 Antikörper (AA 894-898)

Produktnummer ABIN362728

Produktdetails anti-GRIN1/NMDAR1 Antikörper

Target: GRIN1/NMDAR1 (GRIN1) (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1))

Bindungsspezifität: AA 894-898

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GRIN1/NMDAR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: The antibody detects endogenous level of total NMDAR1protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Peptide sequence around AA 894-898 (R-R-S-S-K) derived from Human NMDAR1. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blotting: 1:500-1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Details zu GRIN1/NMDAR1

Target: GRIN1/NMDAR1 (GRIN1) (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1))

Andere Bezeichnung: NMDAR1 (GRIN1 Produkte)

Synonyme: GluN1 antikoerper, MRD8 antikoerper, NMDA1 antikoerper, NMDAR1 antikoerper, NR1 antikoerper, nmda1 antikoerper, nmdar1 antikoerper, GB19253 antikoerper, GRIN1 antikoerper, NMD-R1 antikoerper, Z16 antikoerper, GluRdelta1 antikoerper, GluRzeta1 antikoerper, M100174 antikoerper, Nmdar antikoerper, Rgsc174 antikoerper, NMDAR1.1 antikoerper, zgc:152678 antikoerper, glutamate ionotropic receptor NMDA type subunit 1 antikoerper, glutamate receptor, ionotropic, N-methyl D-aspartate 1 S homeolog antikoerper, NMDA receptor 1 antikoerper, G protein-regulated inducer of neurite outgrowth 1 antikoerper, glutamate receptor, ionotropic, NMDA1 (zeta 1) antikoerper, glutamate receptor, ionotropic, N-methyl D-aspartate 1a antikoerper, GRIN1 antikoerper, grin1.S antikoerper, grin1 antikoerper, Grin1 antikoerper, Nmdar1 antikoerper, Gprin1 antikoerper, grin1a antikoerper

Hintergrund: NMDA receptors are members of the ionotropic class of glutamate receptors, which also includes Kainate and AMPA receptors. NMDA receptors consist of NR1 subunits combined with one or more NR2 (A-D) or NR3 (A-B) subunits. The ligand-gated channel is permeable to cations including Ca2+, and at resting membrane potentials NMDA receptors are inactive due to a voltage-dependent blockade of the channel pore by Mg2+. NMDA receptor activation, which requires binding of glutamate and glycine, leads to an influx of Ca2+ into the postsynaptic region where it activates several signaling cascades, including pathways leading to the induction of long-term potentiation (LTP) and depression (LTD). NMDA receptors have a critical role in excitatory synaptic transmission and plasticity in the CNS. They govern a range of physiological conditions including neurological disorders caused by excitotoxic neuronal injury, psychiatric disorders and neuropathic pain syndromes.

Molekulargewicht: 120 kDa

NCBI Accession: NP_000823

UniProt: Q05586

Pathways: Synaptic Membrane, Feeding Behaviour, Regulation of long-term Neuronal Synaptic Plasticity