Nuclear Stain of Multiple Gene Products Including Nup62, Nup133 Antikörper

Produktnummer ABIN361356

Produktdetails

Target: Nuclear Stain of Multiple Gene Products Including Nup62, Nup133

Reaktivität: Saccharomyces cerevisiae

Wirt: Maus

Klonalität: Monoklonal

Applikation: Immunofluorescence (IF)

Spezifität: Reacts with a nuclear pore complex protein.

Kreuzreaktivität: Human, Maus, Ratte (Rattus)

Aufreinigung: Protein G purified culture supernatant

Immunogen: Yeast nuclear preparations

Klon: 39C7

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Recommended Dilution: IF: 1:50-1:100 Quality Control: Immunofluorescence performed on each lot.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: total IgG fraction + 10 mM Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Antigendetails

Target: Nuclear Stain of Multiple Gene Products Including Nup62, Nup133

Hintergrund: The nuclear pore complex (NPC) is a very large structure made up of at least 50 different proteins that span the double membrane of the nuclear envelope functioning as a gateway for macromolecular traffic between the cytoplasm and the nucleus (Nakielny and Dreyfuss,1999). Discrete nuclear pore complex proteins or nucleoporins such as NUP98, NUP180 and p62 have been implicated in autoimmune disease and cancer. Patients with primary biliary cirrhosis (PBC) frequently produce autoantibodies against p62 and NUP180 (Wilken et al., 1993, Nesher et al., 2001) while NUP98 translocations have been found in patients with acute myelogenous leukemia (AML) (Jaju et al. 2001).