CUL9 Antikörper (C-Term)

Produktnummer ABIN356104

Produktdetails anti-CUL9 Antikörper

Target: CUL9 (Cullin 9 (CUL9))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CUL9 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Kreuzreaktivität: Human, Maus, Ratte (Rattus)

Aufreinigung: affinity purified

Immunogen: 17 amino acid synthetic peptide from near the carboxy terminus of human PARC.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Lagerung: -20 °C

Details zu CUL9

Target: CUL9 (Cullin 9 (CUL9))

Andere Bezeichnung: PARC/P53-associated Parkin-like Cytoplasmic Protein (CUL9 Produkte)

Synonyme: H7AP1 antikoerper, PARC antikoerper, RP3-330M21.2 antikoerper, parc antikoerper, 1810035I07Rik antikoerper, Cul-9 antikoerper, Parc antikoerper, mKIAA0708 antikoerper, RGD1562008 antikoerper, cullin-9 antikoerper, cullin 9 antikoerper, cullin-9 antikoerper, CUL9 antikoerper, LOC100083225 antikoerper, cul9 antikoerper, LOC100561099 antikoerper, Cul9 antikoerper

Hintergrund: PARC (p53 associated parkin like cytoplasmic protein) antibody directly interacted and formed an approximately 1MD complex with p53 in the cytoplasm of unstressed cells. In the absence of stress, inactivation of PARC induced nuclear localization of endogenous p53 and activated p53 dependent apoptosis. Overexpression of PARC promoted cytoplasmic sequestration of ectopic p53. Furthermore, abnormal cytoplasmic localization of p53 was observed in a number of neuroblastoma cell lines, RNA interference-mediated reduction of endogenous PARC significantly sensitized these neuroblastoma cells in the DNA damage response. These results revealed that PARC is a critical regulator in controlling p53 subcellular localization and subsequent function.