CACNA1E
Reaktivität: Human
IF (p), IF (cc)
Wirt: Kaninchen
Polyclonal
AbBy Fluor® 555
Applikationshinweise
IHC, WB. A concentration of 10-50 μg,ml is recommended. The optimal concentration should be determined by the end user. Not tested in other applications.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Lyophilized
Rekonstitution
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handhabung
Avoid freeze and thaw cycles.
Lagerung
4 °C/-20 °C
Informationen zur Lagerung
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Haltbarkeit
12 months
Target
CACNA1E
(Calcium Channel, Voltage-Dependent, R Type, alpha 1E Subunit (CACNA1E))
Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel, and partially by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), omega-conotoxin-GVIA (omega-CTx-GVIA), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels contaning alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing. Subcellular location: Membrane, Multi-pass membrane protein. Tissue specificity: Expressed in neuronal tissues and in kidney.,Alpha Subunit,Voltage-dependent R-type calcium channel subunit alpha-1E, Voltage-gated calcium channel subunit alpha Cav2.3, Calcium channel, L type, alpha-1 polypeptide, Brain calcium channel II, CACH6, CACNL1A6